Anatomy of a transplant: 13 lives, 17 days
Some members of the Pediatric Transplant Center team who performed a record number of transplants in January pose for a picture. It was “lucky 13” for the Boston Children’s Hospital Pediatric Transplant Center this January. Thirteen lives were saved by organ transplantation. Seven kidneys, three hearts, two livers and one pair of lungs were transplanted during the record-breaking month. So what does it take to perform 13 transplants in 17 days? “It takes a team,” says Dr. Heung Bae Kim, director of the Boston Children’s Pediatric Transplant Center. “We are very fortunate to have the talent and the resources necessary, so that when we call and say, ‘We have this many kids coming in for transplants,’ the team is ready, no matter what.” Sixteen-year-old TJ Gregory is one of the lucky 13. He received a heart transplant in mid-January. He had been on the waiting list since October. Born with a serious heart defect called transposition of the great arteries, in which two main arteries leaving the heart are reversed, TJ has struggled with heart issues his entire life. At 40 days old, he had already undergone two open-heart surgeries. “I was watching a playoff game on TV when Dr. [Elizabeth] Blume (medical director, Boston Children’s Heart Transplant Program) called and asked what I was doing,” says TJ’s dad Todd Gregory, “I told her I was watching the game and she said, ‘Do you think...
Publication date: Available online 5 November 2018Source: Autoimmunity ReviewsAuthor(s): Eyal Grunebaum, Yaron AvitzurAbstractIn recent years, the cross talk between the liver and the immune system is being uncovered, in part by studying liver involvement in primary immune deficiencies (PID) and in part by investigating the alterations of the immune system following orthotic liver transplantation (OLT). Here we review some of the reciprocal interactions between the liver and the immune system. Patients with PID, particularly those involving inherited defects in T and B cells or innate immunity are prone to infections and i...
Conditions: Kidney Diseases; Kidney Failure; Kidney Disease, Chronic Intervention: Sponsors: Wake Forest University Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National Institute on Minority Health and Health Disparities (NIMHD); National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
American Journal of Transplantation, EarlyView.
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 35-year-old woman is evaluated for intermittent fever, sweats, fatigue, and dull midchest pain of 2 weeks’ duration. Medical history is significant for liver transplantation 6 months ago for primary biliary cirrhosis; she was seronegative for cytomegalovirus and Epstein-Barr virus, and her donor was positive for both. Results of pretransplant testing for tuberculosis were negative. She received valganciclovir prophylaxis for 3 months after transplantation. Medications are tacrolimus, prednisone, ...
(NIH/National Institute of Allergy and Infectious Diseases) The first large-scale clinical trial to study kidney transplantations between people with HIV has begun at clinical centers across the United States. The HOPE in Action Multicenter Kidney Study will determine the safety of this practice by evaluating kidney recipients for potential transplant-related and HIV-related complications following surgery. The study is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Condition: Hiv Intervention: Other: HIV D+/R+ Sponsors: Johns Hopkins University; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
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