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Anatomy of a transplant: 13 lives, 17 days

Some members of the Pediatric Transplant Center team who performed a record number of transplants in January pose for a picture. It was “lucky 13” for the Boston Children’s Hospital Pediatric Transplant Center this January. Thirteen lives were saved by organ transplantation. Seven kidneys, three hearts, two livers and one pair of lungs were transplanted during the record-breaking month. So what does it take to perform 13 transplants in 17 days? “It takes a team,” says Dr. Heung Bae Kim, director of the Boston Children’s Pediatric Transplant Center. “We are very fortunate to have the talent and the resources necessary, so that when we call and say, ‘We have this many kids coming in for transplants,’ the team is ready, no matter what.” Sixteen-year-old TJ Gregory is one of the lucky 13. He received a heart transplant in mid-January. He had been on the waiting list since October. Born with a serious heart defect called transposition of the great arteries, in which two main arteries leaving the heart are reversed, TJ has struggled with heart issues his entire life. At 40 days old, he had already undergone two open-heart surgeries. “I was watching a playoff game on TV when Dr. [Elizabeth] Blume (medical director, Boston Children’s Heart Transplant Program) called and asked what I was doing,” says TJ’s dad Todd Gregory, “I told her I was watching the game and she said, ‘Do you think...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & Conditions Health & Wellness Our Patients’ Stories double lung transplant Heart Center heart transplant Heart transplant program kidney transplant Liver transplant Lung Transplant Program Pediatric Transplant Center (PTC) Source Type: news

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Condition:   Hiv Intervention:   Other: HIV D+/R+ Sponsors:   Johns Hopkins University;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: In this high risk cohort, a significant proportion of patients who were statin eligible including diabetics, were not prescribed statin. Less than half of renal transplant recipients had a lipid panel documented pre and post- transplant. Patterns of use of cardioprotective medications in the renal transplant population, and its relation to renal and cardiac outcomes needs further study.
Source: Circulation: Cardiovascular Quality and Outcomes - Category: Cardiology Authors: Tags: Session Title: Poster Session PM Source Type: research
Abstract BACKGROUND: Transplantation-acquired food allergies (TAFA) are frequently reported and considered to be caused by immunosuppressive therapy. The aim of this study was to investigate the allergic and immunologic responses in children who had liver or kidney transplantations. METHODS: Twelve children receiving liver transplantations and 10 children receiving kidney transplantations were investigated. All children underwent the allergy work-up and in most of them, lymphocyte screening and serum cytokine measurements were also performed. RESULTS: TAFA were found in 7/12 (58%) children with liver tra...
Source: Allergologia et Immunopathologia - Category: Allergy & Immunology Authors: Tags: Allergol Immunopathol (Madr) Source Type: research
Kidney transplantation is associated with a recruitment of immune cells into the allograft mediated by release of multiple chemokines from parenchymal cells, endothelium and immune cells.The aim of this study was to correlate serum levels of selected chemokines with proportions of immune cells in the peripheral blood of kidney allograft recipients.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Ladies and Gentlemen, this is the moment you have all been waiting for – the day that the winners of the Medgadget Medical Sci-Fi Competition are announced and their fantastic stories are published! First, we would like to thank Eko Devices, th...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Source Type: blogs
Dutch suturing tech company Mellon Medical said today that it has raised €6 million (equivalent to about $6.6 million) to advance its Switch instrument. Mellon Medical officials boast that their Switch single use precision-suturing instrument enables surgeons to suture tubular and layered structures about twice as fast as conventional methods. Reduced clamp time for many cardiovascular procedures equals reduced complications risk, better patient outcomes and reduced costs, according to the company. “By collaborating with medical specialists, industrial designers and ergonomic experts in the development...
Source: Mass Device - Category: Medical Devices Authors: Tags: Business/Financial News News Well mellonmedical surgery Source Type: news
UCLA, UC San Francisco and City of Hope have received a five-year, $8 million grant from the National Institute of Allergy and Infectious Diseases to study how a common virus called cytomegalovirus may provoke the immune system to reject transplanted kidneys.The 14-member interdisciplinary team is co-led by Elaine Reed, who holds the Daljit S. and Elaine Sarkaria Endowed Chair in Diagnostic Medicine at UCLA and is director of the UCLA Immunogenetics Center.  “Nearly 70 percent of people around the world carry antibodies to the cytomegalovirus infection, yet healthy people rarely display symptoms,” said Ree...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
The present study reports a case of piperacillin-induced thrombocytopenia in a dual heart and kidney transplant patient on January 28, 2016 (taking mycophenolate mofetil and tacrolimus). Before the transplant, the patient was treated with Zosyn twice, with no reports of thrombocytopenia or allergy. However, he was diagnosed with heparin-induced thrombocytopenia and vancomycin allergy during each of those hospitalizations, respectively. Eight months after the transplant, the patient presented with infectious symptoms and was started on Zosyn.
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Source Type: research
Conclusion: Relative to CDI, mrCDI incidence has disproportionately increased, indicating a rising demand for mrCDI therapies. Primary Funding Source: National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Allergy and Infectious Diseases. PMID: 28672282 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
In this study, we have evaluated whether acute rejection after kidney transplantation was associated with predicted NK cell alloreactivity based on KIR gene and ligand along with KIR/HLA compound genotype analysis. After kidney transplantation, natural killer (NK) cells play a pivotal role in triggering the immune response to the allogeneic grafts primarily by their killer-cell immunoglobulin-like receptors (KIR). This process may be one mechanism that contributes to graft rejection. In this study, we have evaluated whether acute rejection after kidney transplantation was associated with predicted NK cell alloreactivity ba...
Source: Iranian Journal of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Iran J Allergy Asthma Immunol Source Type: research
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