Two new cembranic diterpenoids from the flowers of Nicotiana tabacum L.

Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Xiao-Feng He, Xiao-Dong Hou, Xia Ren, Kai Guo, Xiu-Zhuang Li, Zhi-Qiang Yan, Yong-Mei Du, Zhong-Feng Zhang, Bo Qin Two new cembranoids, together with fifteen known ones, were isolated from the flowers of Nicotiana tabacum L. The structures of the new compounds were established as (1βH,2E,4αOH,6αOH,7E,10αH,11αH,12βOH)-10,11-epoxy-2,7-cembradiene-4,6,12-triol (1) and (1βH,2E,4αOH,6αOH,7E,10βH,11βH,12αOH)-10,11-epoxy-2,7-cembradiene-4,6, 12-triol (2) by using spectroscopic analysis, including HRESIMS, IR, one- and two-dimensional NMR. A plausible biogenetic relationship of the isolated cembranoids was proposed. The antitumor activities of selected compounds against a panel of three human cancer HepG2, A549 and HCT-116 cell lines were evaluated by the MTT assay. Compound 5 exhibited moderate activity against Hep-G2 cell lines with an IC50 value of 14.38μM. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research