Lyme: The Infectious Disease Equivalent of Cancer, Says Top Duke Oncologist
Last week, I mentioned the case of Dr. Neil Spector, whose long-undiagnosed Lyme Disease resulted in irreversible heart failure and ultimately, a heart transplant. Dr. Spector, author of Gone in a Heartbeat: A Physician's Search for True Healing, is the Sandra Coates Associate Professor of Medicine and Associate Professor of Pharmacology and Cancer Biology at Duke University School of Medicine. As the Director of Developmental Therapeutics at the Duke Cancer Institute, he's a leader in applying translational research to the clinical development of molecularly targeted personalized cancer therapies. Here, Dr. Spector shares his story, explains what Lyme and cancer have in common (hint: a LOT), and encourages us with his vision for the future. Like so many of us, your Lyme was missed by multiple physicians. What were your symptoms? I don't recall a tick bite, but I first started having symptoms in 1993, mostly cardiac arrhythmias. I had unprovoked palpitations that lasted fifteen to twenty seconds. There was something ominous about the way they felt and came on, but they were never captured because by the time I got to the ER, they'd resolve. And because I had just moved to a new state and was extremely busy with my career, the easy diagnosis was that I was just stressed. Doctors were saying I looked and seemed fine, but I wasn't. I also had an early episode of brain fog that came on out of the blue. I gave a lecture at University of Miami School of Medicine for an hour, and...
MRC Laboratory of Molecular Biology researchers reveal atomic structures of the abnormal tau filaments associated with chronic traumatic encephalopathy, a head injury-associated neurodegenerative disease, differ in structure from those seen in Alzheimer’s disease.
ConclusionsFOSL1 is an independent prognostic biomarker of GC. Detecting FOSL1 expression could help stratify GC patients with high-risk and guide the precious treatment.
In this study, we aimed to investigate the role of IL-6/Stat3 signaling pathway in human endometrial cancer cells invasion and migration. We demonstrated that Stat3 is activated in endometrial cancer cell lines. To investigate the role of Stat3 in endometrial cancer invasive capacity, we used Stat3 inhibitor Stattic and found that Stattic significantly inhibited the migration and invasion of endometrial cancer cells elevated by IL-6. Furthermore, we showed that Stat3 inhibitor significantly decreased the expression of MMP2 enhanced by IL-6, indicating that IL-6 promoted endometrial cancer invasion and migration by Stat3-in...
Publication date: Available online 19 March 2019Source: Pathology - Research and PracticeAuthor(s): Xiaobo He, Ying ShuAbstractIncreasing evidence has shown that dysregulation of mircoRNA (miRNA) is linked to the development and progression of human cancer, including gastric cancer (GC). In the current study, by analysing the GEO database (GSE78091), we found that miR-660 was significantly downregulated in GC. Consistently, quantitative real-time PCR (qRT-PCR) results showed that miR-660 was dramatically decreased in GC tissues and cell lines. Importantly, low miR-660 expression was closely related to larger tumor size (P&...
ConclusionsThe results pointed out that the high expression of miR-106b-5p serves as an independent factor for predicting the worse prognosis of RCC patients.
Conclusions: DIM is a very rare tumour. The global survival is excellent. Conservative treatment with PT is an efficient alternative to enucleation and allows good local tumour control. Cataract and glaucoma are the main radiation-related complications, but the corneal status was excellent due to the stem cell harvest prior to radiotherapy.Ocul Oncol Pathol
Conclusion: There are no relevant differences between men and women in ocular or patient survival after brachytherapy for uveal melanoma.Ocul Oncol Pathol
Conclusions: Conjunctival melanocytic lesions suspicious for melanocytoma should be bleached to evaluate their cytologic features. CD68 can be helpful in identifying heavily pigmented melanomacrophages which may mimic a melanocytoma. As conjunctival melanocytomas are extremely rare, their pathogenesis may be different from that of other conjunctival nevi.Ocul Oncol Pathol
Conclusion: We found a statistically significant lower rate of postinjectional local antibiotic therapy and operating room-based procedures among the streptococcus-induced cases compared to cases caused by other organisms.Ophthalmologica
In conclusion, clinical presentation at time of diagnosis of brain metastases consistently includes neurologic signs and symptoms with persistent headache being the most common. Endometrial cancer patients that present with new neurologic complaints or exam findings should be evaluated for brain metastases.
More News: Allergy & Immunology | Alzheimer's | Antibiotic Therapy | Arrhythmia | Arthritis | Autoimmune Disease | Benadryl | Biology | Borrelia | Brain | Brain Cancers | Breast Cancer | Cancer | Cancer & Oncology | Cancer Therapy | Cardiac Arrhythmia | Cardiology | Cervical Cancer | Chemotherapy | Doxycycline | Drugs & Pharmacology | Fibromyalgia | Gastric (Stomach) Cancer | Head and Neck Cancer | Heart | Heart Failure | Heart Transplant | Helicobacter Pylori | Infectious Diseases | Laboratory Medicine | Lupus | Lyme Disease | Lymphoma | Melanoma | Men | Molecular Biology | Neurology | Neuroscience | Nightmares | Rheumatoid Arthritis | Rheumatology | Science | Skin Cancer | Study | Syphilis | Transplant Surgery | Transplants | Websites