Lyme: The Infectious Disease Equivalent of Cancer, Says Top Duke Oncologist

Last week, I mentioned the case of Dr. Neil Spector, whose long-undiagnosed Lyme Disease resulted in irreversible heart failure and ultimately, a heart transplant. Dr. Spector, author of Gone in a Heartbeat: A Physician's Search for True Healing, is the Sandra Coates Associate Professor of Medicine and Associate Professor of Pharmacology and Cancer Biology at Duke University School of Medicine. As the Director of Developmental Therapeutics at the Duke Cancer Institute, he's a leader in applying translational research to the clinical development of molecularly targeted personalized cancer therapies. Here, Dr. Spector shares his story, explains what Lyme and cancer have in common (hint: a LOT), and encourages us with his vision for the future. Like so many of us, your Lyme was missed by multiple physicians. What were your symptoms? I don't recall a tick bite, but I first started having symptoms in 1993, mostly cardiac arrhythmias. I had unprovoked palpitations that lasted fifteen to twenty seconds. There was something ominous about the way they felt and came on, but they were never captured because by the time I got to the ER, they'd resolve. And because I had just moved to a new state and was extremely busy with my career, the easy diagnosis was that I was just stressed. Doctors were saying I looked and seemed fine, but I wasn't. I also had an early episode of brain fog that came on out of the blue. I gave a lecture at University of Miami School of Medicine for an hour, and...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
Background The extent to which cognitive function differs between patients who receive implantable cardioverter-defibrillator (ICD) therapy and patients with heart failure (HF) who do not receive ICD therapy remains to be elucidated. Objectives The aim of this study was to compare the cognitive function between patients with primary or secondary ICDs and patients with HF without an ICD. Methods This descriptive, comparative study included 116 patients who received ICDs and 74 patients with HF who did not receive ICDs. Patients underwent neuropsychological assessment for general cognition, memory, and exec...
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
Background Cognitive impairment is prevalent in heart failure and is associated with higher mortality rates. The mechanism behind cognitive impairment in heart failure with preserved ejection fraction (HFpEF) has not been established. Objective The aim of this study was to evaluate associations between abnormal cardiac hemodynamics and cognitive impairment in individuals with HFpEF. Methods A secondary analysis of Atherosclerosis Risk in Communities (Atherosclerosis Risk in Communities) study data was performed. Participants free of stroke or dementia who completed in-person assessments at visit 5 were in...
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
Conclusions Implantation of an LVAD is associated with significant, nonlinear improvement in short-term memory and global cognitive function, with the most significant improvements occurring in the first 3 months after implantation. Clinicians should anticipate improvements in cognitive function after LVAD implantation and modify postimplantation education to maximize effectiveness of LVAD self-care.
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
Conclusion This study stresses the importance for healthcare professionals to identify SSD and prevent its progression to delirium.
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
Background Health literacy has predicted mortality in heart failure. However, the role of cognitive functioning in this relationship has not been evaluated. We hypothesized that health literacy would predict all-cause mortality but that cognitive functioning would modify the relationship between health literacy and mortality in heart failure. Objective The aim of this study was to examine the association between health literacy, cognitive functioning, and mortality in patients with heart failure. Methods This secondary analysis of a larger study included 298 patients with heart failure with reduced ejecti...
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
Conclusion By identifying classes of biomarkers, providers may be better able to identify patients who are at risk of progressing into advanced HF quicker or those who are more likely to have more severe complications, such as fluid overload or renal disease.
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Precision Health in Cardiovascular Conditions Source Type: research
On December 3,2021, the Food and Drug Administration  approved pembrolizumab (Keytruda, Merck) for the adjuvant treatment of adult and pediatric (≥12 years of age) patients with stage IIB or IIC melanoma following complete resection.
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
The fasting mimicking diet is, in essence, a clever strategy to pull in significant funding for the rigorous study of the use of forms of calorie restriction as a therapy. A fasting mimicking diet involves taking in just few enough calories to trigger most of the benefits of fasting. There must exist a dividing line in calorie intake at which nutrient sensor mechanisms determine that the body is in a state of fasting. Early research into fasting mimicking found that dividing line to be somewhere in the vicinity of 500 to 750 calories daily, but later studies use lower calorie levels. Another important point of calibration ...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
In organ transplant recipients, a third dose of the Moderna COVID-19 vaccine appears to increase neutralizing antibody response against SARS-CoV-2 variants, according to a new study from Canada.Reuters Health Information
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Infectious Diseases News Source Type: news
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