Late liver metastasis of medullary thyroid cancer with low calcitonin levels - successfully cured by radiofrequency.

Late liver metastasis of medullary thyroid cancer with low calcitonin levels - successfully cured by radiofrequency. Endokrynol Pol. 2016 Feb 17; Authors: Al-Salameh A, Baudry C, Gautier JF, Toubert ME, Bihan H, Cohen R Abstract A 28 year-old female consulted in 1994 for a left thyroid nodule known for 2 years with documented progression. Left lobe resection was performed. Total thyroidectomy on September 1994 was performed without lymph node dissection. Pathological examination concluded on unilateral 10x40mm medullary thyroid cancer (MTC). RET mutation was negative. Basal and pentagastrin-stimulated CT levels had been normal from 1994 to 2008 when her CT level was found to be elevated at 33 ng/l and increased subsequently to 111 ng/l in 2010. In accordance with guidelines cervical ultrasound was performed repeatedly with negative findings. After discussion in multi-disciplinary meeting and patient's consent F-Dopa PET scan was proposed in disagreement with guidelines and showed an unique uptake in liver segment VI that was confirmed by MRI. CT levels increased to 253 ng/l when she finally accepted treatment. On February 2013, we performed radiofrequency ablation of the lesion which allowed normalization of CT levels in 2015. This observation highlights the possibility of late recurrence. We could propose that for MTC patients with low calcitonin level-recurrence, F-DOPA-PET/CT is a good diagnostic mean to propose in case of repeate...
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research