Interleukin 35 (IL-35) and IL-35-producing Regulatory B Cells (i35-Bregs): Critical Regulators of Autoimmune Diseases.

Immunology Interest Group Charles E. Egwuagu is Chief of the Molecular Immunology Section, National Eye Institute (NEI), NIH. He received his Ph.D in Epidemiology and Microbiology from Yale University Graduate School and a Master of Public Health (M.P.H) degree in Infectious Disease Epidemiology from Yale School of Medicine, New Haven, Connecticut. Dr. Egwuagu did a 2-year Post-doctoral Fellowship in Molecular Immunology at NEI/NIH and then served as a Commissioned Officer of the United States Public Health Service (PHS) for 10 years, attaining the rank of Captain (06). Research in the Egwuagu laboratory is on autoreactive lymphocytes that mediate CNS autoimmune diseases, such as Uveitis and Multiple Sclerosis. Focus is on cytokine signaling with particular interest in the roles of JAK/STAT pathway and suppressors of cytokine signaling (SOCS) proteins in the regulation of lymphocyte development and cell-fate decisions. Beginning with his seminal finding that susceptibility or resistance to organ-specific autoimmune disease is inversely correlated with expression level of the relevant autoantigen in the thymus, his work evolved towards characterization of lymphocyte subsets that mediate uveitis. These studies culminated in an important paper in Nature Medicine showing that Th17 cells mediate uveitis and are inhibited in the neuroretina by Interleukin 27 (IL-27). More recently his lab discovered a novel regulatory B cell population that produces IL-35 (i35-Breg) and now pione...
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