Metformin: an Old Therapy that Deserves a New Indication for the Treatment of Obesity
Abstract Metformin is not currently used for weight loss or diabetes prevention because it lacks an FDA indication for obesity and/or pre-diabetes treatment. Based on the evidence, metformin has been shown to decrease the incidence of type 2 diabetes, and compares favorably to other weight-loss medications in terms of efficacy as well as safety. Thus, metformin should be considered for a treatment indication in patients with these conditions.
The study highlights the dominance of obesity as a risk factor for type 2 diabetes and reinforces the"importance of weight management in diabetes prevention...in all genetic risk groups," say researchers.Medscape Medical News
Conclusion Our study provides novel evidence that EXE-induced antisenescence against metabolic distress in the hippocampus may be a key neuroprotective mechanism, preventing neuroinflammation and oxidative stress.
Purpose Low-attenuation muscle (LAM) area at mid-thigh, a computed tomography (CT)–derived index of intramuscular lipids, is associated with insulin resistance, obesity, and type 2 diabetes. The present study aimed at testing the hypothesis that changes in LAM area in trunk muscles from a single abdominal scan could provide relevant information to evaluate the effects of a lifestyle intervention without the use of a mid-thigh CT scan. Methods Cardiometabolic risk variables, including waist circumference, lipoprotein–lipid profile, glucose tolerance, and cardiorespiratory fitness, were assessed in a sample ...
2019 NIDDK Administrative Speaker Series The series is an opportunity for NIDDK staff to learn about the important science NIDDK conducts and supports. It is also an excellent way to inspire our administrative staff, as it allows them a chance to hear and see how their roles contribute to and/or impact the work of the scientists.Air date: 10/9/2019 1:00:00 PM
Research presented at the Annual Meeting of the European Association for the Study of Diabetes in Barcelona has linked obesity to a nearly 6-fold increased risk of developing type 2 diabetes, and proves the most dominant risk factor over others such as genetics and lifestyle.Medical Xpress
People with poor lifestyle and obesity are at greater risk of incident T2D – regardless of their genetic risk Related items fromOnMedica Majority of patients ignorant of obesity link to cancer Health system ‘all too often’ lets down people with diabetes Many patients ignore symptoms of diabetes Annual diabetes checks still being missed Tackling obesity ‘must be made a national priority’
ConclusionThese results support the need for a controlled trial of metformin in children with FXS under 7 years old whose brains are in a critical developmental window and thus may experience a greater degree of clinical benefit from metformin.
AbstractPurpose of ReviewRecent advances in genomics provide opportunities for novel understanding of the biology of human traits with the goal of improving human health. Here, we review recent obesity and type 2 diabetes (T2D) –related genomic studies in African populations and discuss the implications of limited genomics studies on health disparity and precision medicine.Recent FindingsGenome-wide association studies in Africans have yielded genetic discovery that would otherwise not be possible; these include identification of novel loci associated with obesity (SEMA-4D,PRKCA,WARS2), metabolic syndrome (CA-10,CTNN...
Patients with obesity and type 2 diabetes who underwent bariatric surgery were less likely than those on medical treatment to have coronary, cerebrovascular or kidney events, in new observational data.Medscape Medical News
'Sensibly optimistic systematic review does not provide definitive evidence that true incidence is falling ’ Related items fromOnMedica Scotland reveals target of halving child obesity by 2030 Obesity as cause of cancer set to overtake smoking Should we recognise obesity as a disease? Type 2 diabetes in 10 times more young people than realised Even athletes can ’t outrun the effects of a bad diet