Tripartite Motif 32 Prevents Pathological Cardiac Hypertrophy

In conclusion, our study indicates that TRIM32 plays a protective role in AB-induced pathological cardiac remodeling by blocking Akt-dependent signaling. Therefore, TRIM32 could be a novel therapeutic target for the prevention of cardiac hypertrophy and heart failure.

Source: Clinical Science - February 16, 2016 Category: Biomedical Science Authors: Chen, L., Huang, J., Ji, Y., Zhang, X., Wang, P., Deng, K., Jiang, X., Ma, G., Li, H. Tags: PublishAheadOfPrint Source Type: research