Postpartum pathology in Yankasa ewes experimentally infected with Trypanosoma evansi during pregnancy

Abstract The study was designed to determine the pathological changes in postpartum Yankasa ewes experimentally infected with Trypanosoma evansi (T. evansi) during pregnancy. Thirteen pregnant Yankasa ewes were divided into two groups comprising six ewes in group A and seven ewes in group B. Ewes in group A served as the uninfected control while ewes in group B were infected with approximately 1.0 × 106 of T. evansi per ewe through the jugular vein at the second trimester of pregnancy. They were closely monitored for trypanosomosis from the time of infection up till parturition. One ewe from each group was humanely sacrificed 10 days postpartum and examined for pathological changes. At postmortem, no gross lesion was seen in the infected and control ewes and their placenta. Histologically, there were no changes on the placenta, reproductive tract (ovary, oviduct, uterus, cervix), and viscera organs (liver, lungs, heart, kidney, and spleen) of both infected and control ewes. However, the infected ewe had histopathological changes in the hypothalamus characterized by neuronal degeneration and microglial infiltration, while in the pituitary gland, there was mononuclear cell infiltration. The thyroid gland was infiltrated by inflammatory macrophages and lost its glandular secretions. All these histopathological changes were absent in the uninfected ewe, suggesting that T. evansi is capable of disrupting the endocrine function of reproduction...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Publication date: Available online 16 July 2019Source: Reproductive ToxicologyAuthor(s): Barbara A. Cohn, Michele A. La Merrill, Nickilou Y. Krigbaum, Miaomiao Wang, June-Soo Park, Myrto Petreas, Gregory Yeh, Russell C. Hovey, Lauren Zimmermann, Piera M. CirilloAbstractWe tested the hypothesis that maternal perinatal serum levels of poly and perfluoroalkyl substances (PFASs) predict risk for breast cancer in daughters in a 54-year follow-up of 9300 daughters born 1959–1967 in the Child Health and Development Studies pregnancy cohort. Total cholesterol and PFASs were measured in archived maternal perinatal serum for 1...
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
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Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Emma Ginn, the director of Medical Justice, warns that women in immigration detention receive inadequate healthcareYou report how a pregnant rape survivor experiencing a miscarriage and barely able to stand was unlawfully held in immigration detention which amounted to inhuman and degrading treatment (Home Office pays £50,000 to trafficked woman detained during miscarriage, 20 August).This case show precisely why the Home Office must heed our advice and that of the medical profession, and actually ban the detention of pregnant women.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Immigration and asylum Women Pregnancy Health & wellbeing Home Office Politics Medical research Human rights Source Type: news
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Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Condition:   Pregnancy Intervention:   Other: Video education Sponsor:   United States Naval Medical Center, San Diego Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Pathology Research and Practice - Category: Pathology Source Type: research
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Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Ob/Gyn & Women ' s Health News Source Type: news
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Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
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Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
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