Expression of lipoxin A4, TNFα and IL-1β in maternal peripheral blood, umbilical cord blood and placenta, and their significance in pre-eclampsia.

CONCLUSIONS: The level of lipoxin A4 in maternal peripheral blood may correlate with the expression of FPR2/ALX in placenta. Lipoxin A4 increased to a lesser degree than either TNFα or IL-1β with progression of PE. This may be one of the reasons why oxidative stress and endothelial dysfunction in severe preeclamptic patients are much more serious that in cases of less severe preeclampsia. Moreover, lipoxin A4 does not have any effect on the fetus through the placenta. We conclude that supplementing with lipoxin A4 to ensure adequate levels may be a novel method for the treatment of pre-eclampsia without any effects on the fetus. PMID: 24960456 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/24960456?dopt=Abstract

Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research