The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15

In conclusion, our findings indicate the potential of PBOX-15 to improve the apoptotic response of IM in GIST cells and provide a more effective treatment option for GIST patients.

http://link.springer.com/10.1007/s10637-016-0331-1

Source: Investigational New Drugs - February 17, 2016 Category: Drugs & Pharmacology Source Type: research