MRL/MpJ-Fas(lpr) mice show abnormalities in ovarian function and morphology with the progression of autoimmune disease.

In conclusion, MRL/lpr mice display altered ovarian development, morphology and function consistent with the progression of severe autoimmune disease, as these findings are less severe in MRL/+ counterparts. PMID: 25857350 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/25857350?dopt=Abstract

Source: Autoimmunity - February 17, 2016 Category: Allergy & Immunology Tags: Autoimmunity Source Type: research