Non-acidic activation of pain-related Acid-Sensing Ion Channel 3 by lipids

Extracellular pH variations are seen as the principal endogenous signal that triggers activation of Acid-Sensing Ion Channels (ASICs), which are basically considered as proton sensors, and are involved in various processes associated with tissue acidification. Here, we show that human painful inflammatory exudates, displaying non-acidic pH, induce a slow constitutive activation of human ASIC3 channels. This effect is largely driven by lipids, and we identify lysophosphatidylcholine (LPC) and arachidonic acid (AA) as endogenous activators of ASIC3 in the absence of any extracellular acidification. The combination of LPC and AA evokes robust depolarizing current in DRG neurons at physiological pH 7.4, increases nociceptive C-fiber firing, and induces pain behavior in rats, effects that are all prevented by ASIC3 blockers. Lipid-induced pain is also significantly reduced in ASIC3 knockout mice. These findings open new perspectives on the roles of ASIC3 in the absence of tissue pH variation, as well as on the contribution of those channels to lipid-mediated signaling.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Membrane & Intracellular Transport, Neuroscience Articles Source Type: research

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Source: Journal of Sport Rehabilitation - Category: Sports Medicine Tags: J Sport Rehabil Source Type: research
Authors: Fyock M, Cortes N, Hulse A, Martin J Abstract Clinical Scenario: Patellofemoral pain (PFP) is a common knee injury in recreational adult runners, possibly caused by faulty mechanics. One possible approach to reduce this pain is to retrain the runner's gait. Current research suggests that no definitive gold standard treatment for PFP exists. Gait retraining utilizing visual feedback may reduce PFP in both the short and long term. Clinical Question: In adult runners diagnosed with PFP, does gait retraining with real-time visual feedback lead to a decrease in pain? Summary of Key Findings: A literature search...
Source: Journal of Sport Rehabilitation - Category: Sports Medicine Tags: J Sport Rehabil Source Type: research
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Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
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Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
ConclusionsOpioid prescribing has decreased for geriatric patients with minor injuries. However, surgeons have not reduced dosage based on age or fall risk.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Hey all, Now that I am a couple years out of fellowship and in private practice I feel like my idealized view of pain medicine is not more realistic and somewhat more cynical. I was having a discussion with a colleague of mine who recently just graduated fellowship and is excited to start a new job and I was going over some of the realities and biggest points of pain for the pain provider. I was hoping to gain some insight into some other points of frustration or inefficiency other... Biggest Pains of Pain Practice
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
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Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
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Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
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Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
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Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
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