New nor-clerodane-type furanoditerpenoids from the rhizomes of Tinospora capillipes

Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Bin Wang, Peng-Liang Zhang, Ming-Xing Zhou, Tao Shen, Yong-Xin Zou, Hong-Xiang Lou, Xiao-Ning Wang Three new nor-clerodane-type furanoditerpenoids, tinocapillins A–C (1–3), and three known diterpenoids were isolated from the rhizomes of Tinospora capillipes. Their structures were elucidated on the basis of extensive spectroscopic analysis. The absolute configuration of compound 4 was established by single-crystal X-ray diffraction analysis using Cu Kα radiation. Compounds 1, 2, and 5 exhibited moderate inhibitory activity on the proliferation of the A549, Hep G2, Hela, and OS-RC-2 human cancer cell lines. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research