'Statins for the brain' could prevent millions of Alzheimer’s Disease cases

Cambridge University scientists say in future all adults over 30 could be offered the drugs to keep their brain healthy for as long as possible.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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AbstractPurpose of ReviewThe purpose of this article is to review the basic principles of near-infrared spectroscopy (NIRS) and its contemporary role in intracoronary imaging.Recent FindingsNIRS has been demonstrated to effectively detect culprit lesions in acute coronary syndromes (ACS) and to potentially identify vulnerable plaque. Lipid-rich plaques detected by NIRS are also associated with higher incidence of future adverse cardiac events. Plaques with high lipid content detected by NIRS have been shown to predict periprocedural myocardial infarction during percutaneous coronary intervention (PCI). The beneficial effec...
Source: Current Cardiovascular Imaging Reports - Category: Radiology Source Type: research
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Diagnostic Dilemma Source Type: research
AbstractProprotein convertase subtilisin/kexin type 9 (PCSK9)-related discoveries of the turn of the century have translated into substantial novelty in dyslipidemia treatment in the last 5  years. With chronic preventable atherosclerotic cardiovascular diseases (ASCVD) representing an epidemic of morbidity and mortality worldwide, low-density lipoprotein cholesterol (LDL-c) reduction represents a public health priority. By overcoming two major statin-related issues, namely intoleranc e and ineffectiveness, PCSK9 inhibitors have offered a safe and effective option in selected clinical settings where LDL-c reduction is...
Source: High Blood Pressure and Cardiovascular Prevention - Category: Cardiology Source Type: research
To determine whether statin (hydroxymethylglutaryl-CoA reductase inhibitor) therapy is associated with better midterm survival after transcatheter aortic valve implantation (TAVI), the first meta-analysis of currently available studies was performed. To identify all observational comparative studies and randomized controlled trials (RCTs) of statin versus control (no statin) therapy or cohort studies investigating statin treatment as one of covariates in patients undergoing TAVI, PubMed, Web of Science, and Google Scholar were searched through March 2019.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
CONCLUSIONS: GNRI is an independent predictor for OS, MACE, and MACLE in patients with PAD. PMID: 31217396 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
No abstract available
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Editorial Source Type: research
Authors: Wang XL, Qi J, Shi YQ, Lu ZY, Li RL, Huang GJ, Ning BB, Hao LS, Wang H, Hao CN, Li Y, Zhou HS, Duan JL Abstract Statins and therapeutic ultrasound (TUS) have been shown to ameliorate angiogenesis on ischemic hindlimb animals and promote human umbilical vein endothelial cells (HUVECs) tube formation and proliferation. Here, we evaluate the therapeutic effect of TUS in combination with atorvastatin (Ator) therapy on angiogenesis in hindlimb ischemia and HUVECs. After subjecting excision of the left femoral artery, all mice were randomly distributed to one of four groups: Control; Ator treated mice (Ator); TU...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
AbstractPurposeElevated copeptin, a vasopressin marker, is linked to metabolic disease, and obese rats with low-vasopressin concentration had a decreased risk of liver steatosis. We here investigated the association between copeptin and nonalcoholic fatty liver disease (NAFLD) and possible differences in copeptin concentration between ethnicities.MethodsIn this cross-sectional study of 361 South Africans (n = 172 African black, 189 = Caucasian) with a mean age of 45 years and 45% men, plasma copeptin was measured and associated with NAFLD according to a validated fatty liver index accounting for...
Source: Endocrine - Category: Endocrinology Source Type: research
AbstractPurpose of ReviewNon-dialysis-dependent chronic kidney disease (NDD-CKD) patients are at an increased risk of cardiovascular disease (CVD) –related deaths in comparison with the general population. This review summarizes recent guideline recommendations and studies on primary and secondary prevention of traditional cardiovascular (CV) risk factors in those with NDD-CKD.Recent FindingsThe use of antiplatelet agents for primary prevention in CKD is not supported by clinical trial evidence; however, they offer potential benefits when used for secondary prevention of CVD in the absence of an elevated bleeding ris...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
Publication date: September 2019Source: Microchemical Journal, Volume 149Author(s): Mohamed Saleh Elgawish, Moustafa K. Soltan, Mahmoud M. SebaiyAbstractHyperlipidemia and hypertension are common co-morbidities and considerably increase the risk of cardiovascular complications. The combined treatment has been recommended for decades; the lipid-lowering agents, statins, and calcium channel blockers (CCBs) are commonly prescribed to control the situation. Hence, the development of sensitive assay is of great importance for pharmacokinetic and therapeutic drug monitoring of the combined drugs. Herein, simple and robust chroma...
Source: Microchemical Journal - Category: Chemistry Source Type: research
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