Lead time bias in estimating survival outcomes

We read with great interest the article by Govindarajan et al,1 whose aim was to compare the survival outcomes among patients with postcolonoscopy colon rectal cancer (PCCRC), patients with colonoscopy-detected cancers and those diagnosed with CRC with no prior colonoscopy. In this very well written paper, patients with PCCRC showed inferior survival time than colonoscopy-detected cancers, probably due to more advanced stages at diagnosis, while the worse outcomes were observed in those patients with no recent colonoscopy prior to diagnosis. Despite the undoubted interest, an important methodological issue should be considered for the correct interpretation of this finding. In fact, in the ‘detected’ group (namely, those patients with colonoscopy-detected cancer), CRCs were diagnosed at an earlier stage, probably because of an high frequency of screening colonoscopies or examinations performed for asymptomatic indications (no data are provided in this regard). This may introduce an important source of bias,...
Source: Gut - Category: Gastroenterology Authors: Tags: PostScript Source Type: research

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BACKGROUND: In 2016, the American Society of Colon and Rectal Surgeons published a rectal cancer surgery checklist composed of the essential elements of preoperative, intraoperative, and postoperative care for patients undergoing rectal cancer surgery. OBJECTIVE: The purpose of this study was to assess whether compliance with preoperative checklist elements was associated with improved pathologic and 30-day postoperative outcomes after rectal cancer surgery. DESIGN: This was a retrospective cohort study. SETTINGS: The study involved North American hospitals contributing to the American College of Surgeons Nation...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Colorectal Cancer Source Type: research
ConclusionOverall, post colorectal cancer resection to follow up surveillance is inadequate. There is a need to identify barriers to surveillance post colorectal cancer resection and address them.ResumoIntroduçãoA colonoscopia de rastreamento um ano após a ressecção do câncer colorretal é recomendada por todas as principais sociedades, incluindo a National Comprehensive Cancer Network e a Multi Society Task Force dos Estados Unidos.Objetivos do estudoAvaliar a adesão às diretrizes de colonoscopia de rastreamento após ressecção de cânce...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
AbstractBackgroundWe recently reported on a left-sided predominance of colorectal cancers in the young (under age 50). Given the predilection of young African Americans for the disease, we wondered if there may be a difference in the biology of colorectal carcinogenesis between this group and Caucasians.ObjectiveCompare the distribution of colorectal cancer in African American patients and Caucasians under age 50, and describe implications for screening in these groups.PatientsColorectal cancer patients diagnosed under the age of 50 between the years 2000 and 2016. All races other than African American and Caucasian and al...
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
This study to describe the main characteristics of this malignancy regarding age, gender, and anatomical sub site distribution, as well as the main presenting symptoms in Iraqi patients.Patients and methodsPatients with newly-diagnosed CRC by colonoscopy findings and confirmed by histopathological examination of endoscopic colonic biopsies were studied.ResultsSixty three cases with a newly-diagnosed CRC were included in this study. There were 31 (49.2%) males and 32 (50.8%) females. CRC peaked in the 60–69 years old age group (p 
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
Condition:   Colorectal Cancer Intervention:   Device: CB-17-08 SaMD Sponsor:   Cosmo Technologies Ltd Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: This study observed no overall significant associations between green tea consumption and colorectal cancer risk, except that there was a weak trend for greater consumption of green tea with decreased risk of male colon cancer. PMID: 30855678 [PubMed - as supplied by publisher]
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Jpn J Clin Oncol Source Type: research
Condition:   Colo-rectal Cancer Intervention:   Device: MDI Sponsor:   Ceck Cap Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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