A novel role of endothelium in activation of latent pro-membrane type 1 MMP and pro-MMP-2 in rat aorta

Conclusions
We propose that the endothelium under ANGII stimulation acts as a novel and key activator of latent pro-MT1MMP and pro-MMP2 in SMCs of rat aorta. Therefore, endothelium may critically contribute to pathophysiology of aortic stiffness.

Source: Cardiovascular Research - February 12, 2016 Category: Cardiology Authors: Otto, S., Deussen, A., Zatschler, B., Müller, B., Neisser, A., Barth, K., Morawietz, H., Kopaliani, I. Tags: Vascular Biology Source Type: research