Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes

Conclusion These findings establish CM-derived exosomes as key components of the cardio-endothelial communication system which, through intercellular protein complementation, would allow a rapid response from ECs to increase glucose transport and a putative uptake of metabolic fuels from blood to CMs. This CM–EC protein complementation process might have implications for metabolic regulation in health and disease.

http://cardiovascres.oxfordjournals.org/cgi/content/short/109/3/397?rss=1

Source: Cardiovascular Research - February 12, 2016 Category: Cardiology Authors: Garcia, N. A., Moncayo-Arlandi, J., Sepulveda, P., Diez-Juan, A. Tags: Cardiac biology and remodelling Source Type: research