Succinate dehydrogenase inhibition with malonate during reperfusion reduces infarct size by preventing mitochondrial permeability transition

Conclusion
Succinate dehydrogenase inhibition with malonate at the onset of reperfusion reduces infarct size in isolated mice hearts through reduction in ROS production and mitochondrial permeability transition pore opening.

Source: Cardiovascular Research - February 12, 2016 Category: Cardiology Authors: Valls-Lacalle, L., Barba, I., Miro-Casas, E., Alburquerque-Bejar, J. J., Ruiz-Meana, M., Fuertes-Agudo, M., Rodriguez-Sinovas, A., Garcia-Dorado, D. Tags: Cardiac biology and remodelling Source Type: research