1.25 Å resolution structure of an RNA 20-mer that binds to the TREX2 complex

The 1.25 Å resolution H32:R crystal structure of a 20 nt ribonucleotide that binds to the TREX-2 complex with high affinity shows a double-stranded RNA duplex arranged along a crystallographic 31 axis in which the antiparallel chains overlap by 18 nucleotides and are related by a crystallographic twofold axis. The duplex shows C–A, U–U and C–C noncanonical base pairings together with canonical Watson–Crick A–U and G–C pairs and a G–U wobble.

Source: Acta Crystallographica Section F - September 23, 2015 Category: Biochemistry Authors: Valkov, E.Stewart, M. Tags: RNA noncanonical base pair research communications Source Type: research