DopAmide: Novel, Water-Soluble, Slow-Release l-dihydroxyphenylalanine (l-DOPA) Precursor Moderates l-DOPA Conversion to Dopamine and Generates a Sustained Level of Dopamine at Dopaminergic Neurons.

CONCLUSIONS: The slow conversion of DopAmide to l-DOPA provides a sustained level of DA in the dopaminergic cells, shown by the long 6-OHDA steady rotations. The water solubility and improved bioavailability may help reduce medication frequency associated with l-DOPA treatment of PD. Sustained levels of DA might lower the super-sensitization of DA signaling and potentially attenuate l-DOPA adverse effects.
PMID: 26861609 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - February 10, 2016 Category: Neuroscience Authors: Atlas D Tags: CNS Neurosci Ther Source Type: research