Cardiovascular outcomes associated with use of clarithromycin: population based study

This research article looks at current clarithromycin use associated with increased risk of myocardial infarction, arrhythmia, and death compared to current amoxicillin use in adults.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Authors: Song Z, Gao R, Yan B Abstract Cardiovascular disease is still the main cause of morbidity and mortality worldwide. Currently, the frontier of research into cardiovascular disease is the field of non-coding RNA. In this review, information was collected on the use of micro-RNAs as non-invasive biomarkers and their role in pathophysiological processes and therapeutic applications. In the case of microRNA-1 and microRNA-133, the roles and regulatory mechanisms of them are reviewed for arrhythmia, myocardial infarction, diabetic cardiomyopathy, myocardial hypertrophy, cardiomyocyte differentiation, and cell re...
Source: Reviews in Cardiovascular Medicine - Category: Cardiology Tags: Rev Cardiovasc Med Source Type: research
This study aimed to ascertain whether tiotropium/olodaterol (T/O) 5/5 μg fixed-dose combination (FDC) may modulate the risk of main cardiovascular outcomes in COPD patients enrolled in randomized controlled trials (RCTs). A meta-analysis (CRD42017070100) was performed by selecting RCTs reporting raw data from the ClinicalTrials.gov database concerning the impact of T/O 5/5 µg FDC vs. monocomponents on the occurrence of specific cardiovascular serious adverse events: arrhythmia, heart failure, myocardial infarction, and stroke. Data were reported as relative risk and 95% Confidence Interval, and the r...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
Commonest cause of SCD due to cardiac arrhythmia – MCQ – Answer Commonest cause of sudden death due to cardiac arrhythmia – Correct answer: d) Coronary artery disease Though all the rest are primary electrical disorders of the heart with high risk of arrhythmic death, their prevalence is quite low compared to coronary artery disease. Hence ventricular fibrillation secondary to acute myocardial infarction/ischemia and previous myocardial infarction with scar related re-entrant ventricular arrhythmia together contribute a much larger number of sudden arrhythmic deaths in the community. Back to question
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Medicine MCQ - CVS Source Type: blogs
Composed primarily of collagen and strengthened with cross-linked fibers, scar tissue that forms after a heart attack doesn ’t contract as well as healthy muscle tissue. It can therefore compromise the organ’s ability to pump blood, which may lead to heart failure, arrhythmias, and sudden cardiac death. Scientists who developed a therapy that targets such scar formation, or fibrosis, recently brought their strategy a step closer to the clinic. After demonstrating its effectiveness in rodents, their latest work—a randomized, double-blinded pig study—validates the approach in a large-animal model.
Source: JAMA - Category: General Medicine Source Type: research
There are limited data on arrhythmias in acute myocardial infarction with cardiogenic shock (AMI-CS). Using a 17-year AMI-CS population from the National Inpatient Sample, we identified common arrhythmias – atrial fibrillation (AF), atrial flutter, supraventricular tachycardia, ventricular tachycardia (VT), ventricular fibrillation (VF), and atrioventricular blocks (AVB). Admissions with concomitant cardiac surgery were excluded. Outcomes of interest included temporal trends, predictors, in-hospita l mortality, and resource utilization in cohorts with and without arrhythmias.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Authors: Shao C, Wang J, Tian J, Tang YD Abstract In most developed countries, coronary artery disease (CAD), mostly caused by atherosclerosis of coronary arteries, is one of the primary causes of death. From 1990s to 2000s, mortality caused by acute MI declined up to 50%. The incidence of CAD is related with age, gender, economic, etc. Atherosclerosis contains some highly correlative processes such as lipid disturbances, thrombosis, inflammation, vascular smooth cell activation, remodeling, platelet activation, endothelial dysfunction, oxidative stress, altered matrix metabolism, and genetic factors. Risk factors ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
In this study, we report a novel approach for measurement of interstitial cardiac norepinephrine, using minimally invasive electrode-based fast scanning cyclic voltammetry (FSCV) applied in a beating porcine heart. The first multi-spatial- and high temporal- resolution, multi-channel measurements of norepinephrine (NE) release in vivo are provided. Our data demonstrate rapid changes in interstitial NE profiles with regional differences in response to coronary ischemia, sympathetic nerve stimulation, and alterations in preload/afterload. PMID: 32216617 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
ConclusionAdjusting for imbalances in baseline variables that influence outcomes (or the response to therapy or both) can improve the power around the estimate of the effect of treatment and may alter its statistical significance. Along with the CHARM-Preserved results, these findings suggest that angiotensin-receptor blockers may have a modest effect in HFpEF.
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
Abstract Sleep is essential to and an integral part of life and when lacking or disrupted, a multitude of mental and physical pathologies ensue, including cardiovascular (CV) disease, which increase health care costs. Several prospective studies and meta-analyses show that insomnia, short (9h) sleep and other sleep disorders are associated with an increased risk of hypertension, metabolic syndrome, myocardial infarction, heart failure, arrhythmias, CV disease risk and/or mortality. The mechanisms by which insomnia and other sleep disorders lead to increased CV risk may encompass inflammatory, immunological, neuro-...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
Conclusion: A frequent ablation device position changing during the surgery makes it possible to achieve complete left atrial posterior wall and pulmonary veins isolation. An increased number of applications allows to avoid a false positive transmural damage assessment showed by impedance drop. Also, frequent position changing of the ablation device and increased number of applications do not affect the number of postoperative complications.
Source: Revista Brasileira de Cirurgia Cardiovascular - Category: Cardiovascular & Thoracic Surgery Source Type: research
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