The role of neoangiogenesis and vascular endothelial growth factor in the development of carpal tunnel syndrome in patients with diabetes

Conclusion: VEGF expression has an importance within CTS pathogenesis. Increased ischemia-reperfusion damage, neoangiogenesis, and VEGF expression has an important role frequently CTS occurrence in diabetic patients. Our study supports enhancement in VEGF expression similar to changes in diabetic nephropathy and retinopathy in the neovascularization within the subsynovial connective tissue in the cases of diabetes.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research

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Conclusions: Although the majority of diabetic patients were asymptomatic for the UNE, approximately one third of all patients with DM were found to have UNE. Ulnar neuropathy at the elbow is closely related with PNP.
Source: Journal of Clinical Neurophysiology - Category: Neurology Tags: Original Research Source Type: research
A systematic review and meta-analysis.
Source: Journal of Hand Therapy - Category: Rehabilitation Authors: Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
A 72-year-old, 94-kg, 173-cm man with hypertension, diabetes mellitus, obstructive sleep apnea, and a family history of coronary artery disease presented to the authors ’ preoperative evaluation clinic before an elective carpal tunnel release. An electrocardiogram obtained in the clinic showed previously undocumented atrial flutter. The hand surgery was postponed; the patient was referred to the electrophysiology service for further evaluation. He subsequently un derwent a radiofrequency ablation, but then developed recurrent paroxysmal atrial fibrillation after the procedure.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Diagnostic Dilemma Source Type: research
ConclusionsThe high prevalence of indicative signs and symptoms of CTS and the difficulties that they can cause reinforce the importance of adequate diagnosis and treatment. Further studies are needed to assess the value of USG as a diagnostic method for CTS during pregnancy.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
AbstractPurpose of ReviewCarpal tunnel syndrome (CTS) is an entrapment neuropathy that involves the compression of the median nerve at the wrist and is considered the most common of all focal entrapment mononeuropathies. CTS makes up 90% of all entrapment neuropathies diagnosed in the USA and affects millions of Americans.Recent FindingsAge and gender likely play a role in the development of CTS, but additional studies may further elucidate these associations. Of known associated risk factors, diabetes mellitus seems to have the greatest association with CTS. One of the most commonly reported symptoms in CTS is a “pi...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
The objective of this study was to assess the relationship between multiple TF and systemic or musculoskeletal disorders in a sample of young patients.Material and methodA retrospective study was performed of all patients with TF operated in our hospital between 2011 and 2015. Multiple or single TF diagnosis and pathologies such as diabetes mellitus (DM), thyroid dysfunction, carpal tunnel syndrome (CTS), epicondylalgia or DeQuervain's disease were collected. Statistical results included a bivariate analysis and a multiple logistic regression.ResultsTwo hundred and seventy-nine patients with a mean age of 48.45 years ...
Source: Revista Espanola de Cirugia Ortopedica y Traumatologia - Category: Orthopaedics Source Type: research
Authors: Zochodne DW Abstract Peripheral neurons are targeted by a 'double hit' during diabetes mellitus. First, they are damaged directly; diabetic polyneuropathy is a progressive neurodegenerative disorder that involves sensory, autonomic and eventually motor neurons. The second 'hit' involves a profound impairment in the ability of peripheral axons to regenerate. This is important because the impairment impacts on how patients may recover from polyneuropathy. Moreover, diabetic patients also develop direct focal injures of peripheral nerves, such as carpal tunnel syndrome and ulnar neuropathy at the elbow. Their...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
ConclusionThere was no significant association between the patterns of electronic devices use and CTS symptoms. The high prevalence of CTS symptoms necessitates awareness programs, especially among the young population. Although this work did not prove the association, further studies with confirmatory clinical testing are recommended.
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
De Quervain's disease, carpal tunnel syndrome (CTS), and trigger finger (digit) are three common pathological conditions of the hand. They are considered overuse syndromes and occur predominantly in females. The prevalence rate and cause-specific risks of these three tendinopathies have not yet been clarified. Data from 41,871 cases listed in the Taiwan National Health Insurance Research Database (NHIRD) from 2010 to 2014 were analyzed. The prevalence rate of these 3 conditions by age, sex, and the risk factors of female-dominant diseases (e.g., osteoporosis, rheumatoid arthritis [RA], and tendinopathy), diabetes mellitus,...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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