The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster

Conclusions: Drosophila melanogaster presents an advantageous model to study the genetic underpinnings of variation in susceptibility to lead toxicity. Evolutionary conservation of cellular pathways that respond to toxic exposure allows predictions regarding orthologous genes and pathways across phyla. Thus, studies in the D. melanogaster model system can identify candidate susceptibility genes to guide subsequent studies in human populations. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Zhou S, Morozova TV, Hussain YN, Luoma SE, McCoy L, Yamamoto A, Mackay TF, Anholt RR. The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1510513 Received: 20 July 2015 Accepted: 21 January 2016 Advance Publication: 9 February 2016 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EH...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article Source Type: research