The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster
Conclusions: Drosophila melanogaster presents an advantageous model to study the genetic underpinnings of variation in susceptibility to lead toxicity. Evolutionary conservation of cellular pathways that respond to toxic exposure allows predictions regarding orthologous genes and pathways across phyla. Thus, studies in the D. melanogaster model system can identify candidate susceptibility genes to guide subsequent studies in human populations.
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Citation: Zhou S, Morozova TV, Hussain YN, Luoma SE, McCoy L, Yamamoto A, Mackay TF, Anholt RR. The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1510513
Received: 20 July 2015
Accepted: 21 January 2016
Advance Publication: 9 February 2016
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Source: EHP Research - Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research
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