Allosteric Modulation of Sigma-1 Receptors Elicits Rapid Antidepressant Activity.

CONCLUSION: SOMCL-668, a novel allosteric modulator of sigma-1 receptors, elicits a potent and rapid acting antidepressant effect. The present data provide the first evidence that allosteric modulation of sigma-1 receptors may represent a new approach for antidepressant drug discovery. PMID: 26854125 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26854125?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - February 8, 2016 Category: Neuroscience Authors: Wang Y, Guo L, Jiang H, Zheng L, Zhang A, Zhen X Tags: CNS Neurosci Ther Source Type: research