Nicorandil, Gastrointestinal Adverse Drug Reactions and Ulcerations: A Systematic Review

Conclusions Ulcerative disease is a very commonly reported GI ADR. A delayed ulcerative tendency supports the hypothesis of an ulcerogenic metabolite. Nicorandil seems to act as a cause of the ulcerations, but appears to also work in synergy with other promoting factors. Whether the action of the metabolites relies on a specific mechanism or a simple chemical ulceration is still to be established.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research