A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus.

CONCLUSIONS: Both in vitro and in vivo experiments revealed that KPT-350 increased XPO1, AKT, and FOXP1 nuclear expression and relegated NF-k B expression within the neuronal nuclei. Altogether, these findings advance the utility of SINE compounds to stop trafficking of cell death proteins within the nucleus as an efficacious treatment for TBI. PMID: 26842647 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26842647?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Tajiri N, De La Peña I, Acosta SA, Kaneko Y, Tamir S, Landesman Y, Carlson R, Shacham S, Borlongan CV Tags: CNS Neurosci Ther Source Type: research