Weekend Roundup: The Pope Blesses China

Many seem to fear the rise of China as a challenge to the West. Not Pope Francis. In a remarkable interview published this week in Asia Times, he takes the long view, transcending contemporary geopolitics and embracing the return of the Middle Kingdom's ancient civilization to the global stage as enriching for us all. "For me, China has always been a reference point of greatness," the pontiff was quoted as saying. "A great country. But more than a country, a great culture, with an inexhaustible wisdom." It was the first time in 2,000 years that a pope had extended greetings on the Lunar New Year to a Chinese leader. In the interview, Francis referred to the experience of Matteo Ricci, the 16th century Jesuit missionary who in many ways introduced China to the West. "Ricci's experience teaches us that it is necessary to enter into dialogue with China, because it is an accumulation of wisdom and history." We in the West, he further said, have a "duty to respect it with a capital 'R'." Writing from Rome for our "Following Francis" series, Sébastien Maillard explains why the pope is "looking East" to Russia and China, including talk of a possible compromise with Beijing that would allow the Vatican to once again appoint bishops there. Former Hong Kong governor C.H. Tung also invokes history to make his case that China has no desire for world leadership today. "At the height of the Ming Dynasty, when China had...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Pregnant women &vaccines against emerging epidemic threats: Ethics guidance for preparedness, research, and response. Vaccine. 2019 May 03;: Authors: Krubiner CB, Faden RR, Karron RA, Little MO, Lyerly AD, Abramson JS, Beigi RH, Cravioto AR, Durbin AP, Gellin BG, Gupta SB, Kaslow DC, Kochhar S, Luna F, Saenz C, Sheffield JS, Tindana PO, PREVENT Working Group Abstract Zika virus, influenza, and Ebola have called attention to the ways in which infectious disease outbreaks can severely - and at times uniquely - affect the health interests of pregnant women and their offspring. These examples also hig...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Discussion Genome comparison of over 1,230 non-redundant, high quality EBOV full-length sequences within the Zaire lineage revealed both conserved and highly variable regions (Figure 1). The latter were concentrated in non-coding sequences, which were also more AT-rich than coding sequences, an observation that has also been made for other virus species, for instance Hepatitis B virus (González et al., 2018). The AT-content of coding sequences was most likely lower due to codon constraints, though we observe that the gene for RNA polymerase is richer in AT than the other EBOV genes. The analysis further identified ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
CONCLUSIONS: The EIDAR Research Area is responsive to military-relevant infectious disease threats that are also frequently global public health concerns. Several new EIDAR efforts are underway that will provide Combatant Command Surgeons, Infectious Diseases Service Chiefs, and other Force Health Protection stakeholders with epidemiological information to mitigate the impact of EIDs and antimicrobial resistance on the health of U.S. military service members and their dependents. PMID: 31004432 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Abstract Recently, protocols for amplicon based whole genome sequencing using Nanopore technology have been described for Ebola virus, Zika virus, yellow fever virus and West Nile virus. However, there is some debate regarding reliability of sequencing using this technology, which is important for applications beyond diagnosis such as linking lineages to outbreaks, tracking transmission pathways and pockets of circulation, or mapping specific markers. To our knowledge, no in depth analyses of the required read coverage to compensate for the error profile in Nanopore sequencing have been described. Here, we describ...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
Abstract In this two-part series of reviews, we have invited experts in their fields to contribute articles on the status of vaccine research and development for emerging pathogens. This topic has been brought into sharp focus in recent years following significant outbreaks of viral diseases such as those causing severe acute respiratory syndrome and Middle East respiratory syndrome, as well as devastating outbreaks of diseases caused by the Ebola, Marburg, Zika and Lassa fever viruses, to name only a few examples. Additionally, bacterial infections leading to bubonic and pneumonic plague, most notably in Madagasc...
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research
In this study, we evaluated ATA as a potential antiviral drug against ZIKV replication. The antiviral activity of ATA against ZIKV replication in vitro showed median inhibitory concentrations (IC50) of 13.87 ± 1.09 μM and 33.33 ± 1.13 μM in Vero and A549 cells, respectively; without showing any cytotoxic effect in both cell lines (median cytotoxic concentration (CC50)> 1,000 μM). Moreover, ATA protected both cell types from ZIKV-induced cytopathic effect (CPE) and apoptosis in a time- and concentration-dependent manner. In addition, pre-treatment of Vero cells with ATA for up to 72 h also resulted...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Adriano Queiroz1, Isabella Fernanda Dantas Pinto2, Maricélia Lima3, Marta Giovanetti1,4, Jaqueline Goes de Jesus1, Joilson Xavier1, Fernanda Khouri Barreto5, Gisele André Baptista Canuto6, Helineide Ramos do Amaral7, Ana Maria Bispo de Filippis4, Denise Lima Mascarenhas8, Melissa Barreto Falcão8, Normeide Pedreira Santos8, Vasco Ariston de Carvalho Azevedo9, Marcos Yukio Yoshinaga2*, Sayuri Miyamoto2 and Luiz Carlos Junior Alcantara1,4,10* 1Laboratório de Patologia Experimental, Instituto Gonçalo Moniz, Salvador, Brazil 2Departamento de Bioquímica, Instituto de Quími...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Jacobs Robin Ketteler Marcus Dorner Mark Marsh Viruses are a major threat to human health and economic well-being. In recent years Ebola, Zika, influenza, and chikungunya virus epidemics have raised awareness that infections can spread rapidly before vaccines or specific antagonists can be made available. Broad-spectrum antivirals are drugs with the potential to inhibit infection by viruses from different groups or families, which may be deployed during outbreaks when specific diagnostics, vaccines or directly acting antivirals are not available. While pathogen-directed approaches are generally effective against ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Source: National Library of Medicine [National Institutes of Health] (NLM). Published: 2/14/2019. Speakers in this one-hour webinar from the National Library of Medicine (NLM) Disaster Information Management Research Center (DIMRC) discuss several new DIMRC activities, the NLM Exhibition Program ’s new Exhibitions Connect initiative, and the activities of the NLM Web Collecting and Archiving Group. The first speaker details the CHEMM program’s new information about fourth generation agents, and NLM’s events at the 2019 Preparedness Summit on March 26-29. The second speaker highlights the Exhibition Conne...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
Purpose: The West African Ebola outbreak and Zika virus outbreak in the Americas were both initially reported as undiagnosed disease events, underscoring the importance of monitoring and detecting early reports of undiagnosed diseases. The purpose of this study was to examine undiagnosed disease events captured by Public Health England's epidemic intelligence system (EIS) between 2013 and 2017 to inform future epidemic intelligence practices.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 21.065 Source Type: research
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