Antihistamine poisoning

Antihistamines are commonly used to treat allergy, dizziness and nausea. The sedating antihistamines are non-specific in their actions and often have marked anticholinergic effects. Features of toxicity are likely to develop within 6 hours of overdose and include tachycardia, blood pressure disturbances, dry mouth, ataxia, agitation, psychosis and, uncommonly, convulsions or arrhythmias. Sedation is exacerbated by co-ingestion of other central nervous system depressants including alcohol. Non-sedating antihistamines are less toxic in overdose but may cause tachycardia, drowsiness, gastrointestinal disturbances and headache.
Source: Medicine - Category: Internal Medicine Authors: Tags: Specific substances Source Type: research