Allergies, Asthma Tied to Lower Risk of Brain Cancer

Researchers found 30 percent lower odds for those with respiratory allergies and eczema
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Authors: Tags: Dermatology, Oncology, Asthma, Allergy, News, Source Type: news

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In this study, MHC-1 and PDL-1 score in primary and metastatic tumor cells was evaluated in 43 gastric cancer patients with lymph node metastasis. According to our results, the primary tumor PDL-1 score was correlated with the number of metastatic lymph nodes (r = 0.258; p = 0.024) and primary tumor size (r = 0.341; p = 0.045). A similar correlation was found between the primary tumor PDL-1 score and the metastatic tumor PDL-1 score (r = 0.213; p = 0.015). In our study, MHC-1 was found to be higher in primary tumors than metastatic tumors, although not statistically significant (p = 0.054). The results of our study showed ...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Authors: McCarthy AJ, O'Reilly SM, Shanley J, Geraghty R, Ryan EJ, Cullen G, Sheahan K Abstract Background: As the malignant potential of sessile serrated lesions/polyps (SSL/Ps) and traditional serrated adenomas (TSAs) has been clearly demonstrated, it is important that serrated polyps are identified and correctly classified histologically. Aim: Our aim was to characterize the clinicopathological features of a series of SSL/Ps &TSAs, to assess the accuracy of the pathological diagnosis, the incidence, and the rate of dysplasia in SSL/Ps &TSAs. Methods: We identified all colorectal serrated polyps b...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Publication date: Available online 18 March 2019Source: Molecular Aspects of MedicineAuthor(s): Laura Valle, Richarda M. de Voer, Yael Goldberg, Wenche Sjursen, Asta Försti, Clara Ruiz-Ponte, Trinidad Caldés, Pilar Garré, Maren F. Olsen, Margareta Nordling, Sergi Castellvi-Bel, Kari HemminkiAbstractThe present article summarizes recent developments in the characterization of genetic predisposition to colorectal cancer (CRC). The main themes covered include new hereditary CRC and polyposis syndromes, non-CRC hereditary cancer genes found mutated in CRC patients, strategies used to identify novel causal ge...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
Publication date: March 2019Source: Biomolecular Detection and Quantification, Volume 17Author(s): Abel Jacobus Bronkhorst, Vida Ungerer, Stefan HoldenriederAbstractAn increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and monitoring. However, harnessing the full potential of cfDNA requires (i) the optimization and standardization of preanalytical steps, (ii) refinement of current analysis strategies, and, perhaps most importantly, (iii) significant improvements in our understanding of its origin, phys...
Source: Biomolecular Detection and Quantification - Category: Molecular Biology Source Type: research
ConclusionLong non-coding RNA MALAT1 sponged miR-195 to regulate proliferation, apoptosis and migration and immune escape abilities of DLBCL by regulation of PD-L1.
Source: Life Sciences - Category: Biology Source Type: research
Publication date: February 2019Source: Biomedical and Environmental Sciences, Volume 32, Issue 2Author(s): Xiao Yan GAI, Li Jiao ZHANG, Chun CHANG, Cheng Lin GUO, Mairipaiti ABULIKEMU, Wen Xiong LI, Juan WANG, Wan Zhen YAO, Xu ZHANGAbstractObjectiveTo compare the serum glycerophospholipid levels in the inflammatory subtypes of asthma by using targeted metabolomic analysis.MethodsDemographic and clinical data were collected from 51 patients with asthma between January 2015 and December 2015. Routine blood and sputum induction tests were performed. Eosinophilic asthma was defined as induced sputum containing ≥ 3% eosinoph...
Source: Biomedical and Environmental Sciences - Category: Biomedical Science Source Type: research
Researchers found 30 percent lower odds for those with respiratory allergies and eczema
Source: Cancercompass News: Other Cancer - Category: Cancer & Oncology Source Type: news
Researchers found 30 percent lower odds for those with respiratory allergies and eczema
Source: WebMD Health - Category: Consumer Health News Source Type: news
Abstract Individuals with Neurofibromatosis type 1 (NF1) are at increased risk for pediatric brain tumors (PBTs), especially optic gliomas; however, factors influencing their development are largely unknown. Extensive research suggests that allergic conditions protect against brain tumors, particularly gliomas in individuals without NF1. In this large cross-sectional study, we employed two different data sources to evaluate evidence for the hypothesis that allergic conditions (allergies, asthma, and eczema) may protect against PBT development in individuals with NF1. We used self- and parent/legal guardian reporte...
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research
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