FDG PET/CT Findings of Intracardiac Myeloid Sarcoma
We presented here the FDG PET/CT findings of a 66-year-old man with a 3-month history of cough and progressive dyspnea. FDG PET/CT scan demonstrated nonuniform FDG uptake in the cardiac walls and pericardium. Biopsy of the heart revealed myeloid sarcoma. In addition, bone marrow biopsy demonstrated the acute myeloid leukemia.
Contributors : Ling Li ; Xin HeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe want to obtain FLT3-ITD gene signature. To do so, we transduced CB CD34+ cells with mock or FLT3-ITD vectors and performed RNA sequencing (RNA-Seq).Two Groups: Group1: CB CD34+ cells transduced with mock vector; Group2: CB CD34+ cells transduced with FLT3-ITD vector;
Contributors : Samir Devalaraja ; Tsun K To ; Ian W Folkert ; Ramakrishnan Natesan ; Zahidul Alam ; Minghong Li ; Yuma Tada ; Konstantin Budagyan ; Mai Dang ; Li Zhai ; Graham P Lobel ; Gabrielle E Ciotti ; T K Eisinger-Mathason ; Irfan A Asangani ; Kristy Weber ; M C Simon ; Malay HaldarSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe immunosuppressive tumor microenvironment (TME) is a major barrier to immunotherapy. Within solid tumors, why monocytes preferentially differentiate into immunosuppressive tumor associated macrophages (TAMs) but not immunostimulatory dendritic cells (...
Contributors : Elizabeth Ostrander ; Grant A ChallenSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusEpigenetic modifying enzymes DNMT3A and TET2 are recurrently mutated in hematological disorders despite possessing opposing biochemical functions in the DNA methylation processes. Using conditional ablation, we show these contrasting genotypes result in different functional effects in hematopoietic stem cells (HSCs). Loss of Dnmt3a bestows enhanced self-renewal on HSCs in serial, competitive repopulation assays while Tet...
Publication date: Available online 31 March 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Nada Alhazmi, Chun-Peng Pai, Aljawharah Albaqami, Han Wang, Xuan Zhao, Minyue Chen, Po Hu, Shuang Guo, Kyle Starost, Omid Hajihassani, Masaru Miyagi, Hung-Ying Kao
Discussion: A tertiary referral center referred 125 individuals to physiotherapy who were eligible for the study; we finally included 93 individuals for statistical analysis. Multiple backward regression analysis showed that gender (95% confidence interval [CI], 2.05-33.82), weight (95% CI, 0.39-1.02), age (95% CI, −0.91 to −0.04), left handgrip strength (95% CI, 0.14-1.44), and inspiratory muscle strength (95% CI, 0.08-0.38) were all independently associated with muscle surface area at L3. All these variables together explained 66% of the variability (R2) in muscle surface area at L3 (P
Publication date: Available online 30 March 2020Source: Sensors and Actuators B: ChemicalAuthor(s): Judit Randek, Carl-Fredrik Mandenius
J. Mater. Chem. A, 2020, Accepted Manuscript DOI: 10.1039/C9TA14034D, PaperTian Gan, Xinqiang Fan, Ye Liu, Chengyu Wang, Haoran Mei, Lijun Fan, Nianjun Hou, Yicheng Zhao, Yongdan Li Ni/Ce0.8Sm0.2O1.9 (SDC) with a three-dimensionally ordered macroporous (3DOM) structure is prepared with poly(methyl methacrylate) as the template and characterized using X-ray powder diffraction, scanning electron microscopy, transmission electron microscopy, H2... The content of this RSS Feed (c) The Royal Society of Chemistry
I have seen that a few companies are offering paid leave if their workers test positive for COVID19. In theory this is great. In reality, this is bogus. Policies are worded very specifically. Most of the statements I have seen that list paid leave are for patients that TEST positive for COVID19. The problem is we do not have enough tests! At my practice (a large, tertiary, University-based clinic in Southern California), we are operating under the assumption that most people who contract COVID19 will have a mild form of the disease that will not require a hospital admission. However, they will need...
A 69-year-old man presented to our hospital with shortness of breath and cough. He had a history of essential hypertension but no known significant cardiovascular or pulmonary disease. Almost 1 year before the patient was diagnosed with acute myeloid leukemia with detectable mutations of the nucleophosmin 1 (NPM1) and FLT3 internal tandem duplication (FLT3-ITD) gene. After induction chemotherapy, bone marrow aspiration revealed refractory acute myeloid leukemia with blast persistence, and antileukemic therapy was switched to the multikinase inhibitor sorafenib, resulting in cytologic remission.
A 69-year-old man presented to our hospital with shortness of breath and cough. He had a history of essential hypertension but no known significant cardiovascular or pulmonary disease. Almost one year before the patient was diagnosed with acute myeloid leukemia with detectable mutations of the nucleophosmin 1 (NPM1) and FLT3 internal tandem duplication (FLT3-ITD) gene. After induction chemotherapy, bone marrow aspiration revealed refractory acute myeloid leukemia with blast persistence, and antileukemic therapy was switched to the multikinase inhibitor sorafenib resulting in cytological remission.