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With the advent, and reduction in cost, of next-generation sequencing, large-scale studies of diverse cancer types have yielded unparalleled insights into the genetic causes of cancer. The hope is that these sequencing-based studies will inform the development and implementation of targeted therapeutics. Although many studies have focused on the identification of exonic single-nucleotide variants (SNVs), the presence of structural variation in cancer genomes is well documented and is also thought to contribute to both tumorigenesis and cancer progression.
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Editors ’ Corner Source Type: research