Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current Research Trends and Scientific Gaps

Conclusions: Evidence is mounting that relates early-life iAs exposure and cancer development later in life. Future research should include animal studies that address mechanistic hypotheses and studies of human populations that integrate early-life exposure, molecular alterations, and latent disease outcomes.

Citation: Bailey KA, Smith AH, Tokar EJ, Graziano JH, Kim KW, Navasumrit P, Ruchirawat M, Thiantanawat A, Suk WA, Fry RC. 2016. Mechanisms underlying latent disease risk associated with early-life arsenic exposure: current research trends and scientific gaps. Environ Health Perspect 124:170–175; http://dx.doi.org/10.1289/ehp.1409360
Address correspondence to R.C. Fry, Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, 135 Dauer Dr., CB 7431, University of North Carolina, Chapel Hill, NC 27599-7295 USA. Telephone: [phone]. E-mail: [e-mail]
This research was supported by grants from the National Institute of Environmental Health Sciences (P30-ES010126, P42-ES005948, R01-ES019315, T32-ES07018, and P42-ES04705).
The authors declare they have no actual or potential competing financial interests.
Received: 17 October 2014
Accepted: 23 June 2015
Advance Publication: 26 June 2015
Final Publication: 1 February 2016
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Source: EHP Research - February 1, 2016 Category: Environmental Health Authors: Sam Duvall Tags: Commentary February 2016 Source Type: research