Endo's Testosterone Injection Finally Wins FDA Nod

(MedPage Today) -- Testosterone undecanoate for injection (Aveed) has received the FDA's approval for treating male hypogonadism on its third try, its manufacturer announced.
Source: MedPage Today Geriatrics - Category: Geriatrics Source Type: news

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Purpose of review The review presents a clinical algorithm for the evaluation and treatment for adolescents with Klinefelter's syndrome who desire fertility preservation. Recent findings Sperm is present in the ejaculate in around 8% of men with Klinefelter's syndrome. Although most are severely oligospermic/azoospermic, 43–45% of men will have sperm found during a testicular sperm extraction, reaching up to 70% in adolescents. Summary Klinefelter's syndrome (47, XXY) causes hypogonadotophic hypogonadism and severe oligospermia/azoospermia rendering natural conception rare. During puberty, boys often require ...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: GENDER MEDICINE, INFERTILITY AND ERECTILE FUNCTION: Edited by Ryan Flannigan and Ranjith Ramasamy Source Type: research
The relationship between sleep and hypogonadism continues to be elucidated.1 Emerging research suggests that the severity of hypogonadal symptoms may be directly impacted by poor sleep quality.2 Normal sleep architecture can be disrupted in various ways including circadian rhythm disorders, obstructive sleep apnea (OSA), or sleep restriction.3 The present study builds upon prior work by Pastuszak et al to showcase that impaired sleep as identified by shift work sleep disorder (SWSD), may predict the presence of hypogonadal symptoms among male nonstandard shift workers.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
This article validates previous Pastuszak et al in terms of the prevalence of hypogonadism in nonstandard shift works but also further differentiates individuals based on sleep quality.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Condition:   Hypogonadism, Male Interventions:   Other: Testosterone Measurements in healthy volunteers after fasting;   Other: Testosterone Measurements after glucose loading Sponsor:   The Royal Wolverhampton Hospitals NHS Trust Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractKey contentThe World Health Organization (WHO) type 1 anovulatory disorders include hypogonadotrophic hypogonadism, hypothalamic amenorrhoea and hypopituitarism.These conditions are encountered primarily in endocrine, gynaecology and reproductive medicine clinics, and can result in amenorrhoea/oligomenorrhoea, subfertility or pregnancy loss.These conditions are associated with estrogen deficiency and therefore have implications for long ‐term bone and cardiovascular health.There is an apparent lack of clarity on diagnostic criteria (including utility of new biomarkers such as anti ‐müllerian hormone) and m...
Source: The Obstetrician and Gynaecologist - Category: OBGYN Authors: Tags: REVIEWS Source Type: research
The objective of this work, apart from reviewing the currently known genes associated with CHH, was to summarize the advantages and disadvant ages of the NGS-based platforms and through the authors’ own practice to guide through the whole workflow starting from gene panel design, performance analysis and result interpretation. Based on our results, a genetic diagnosis was clearly identified in 21% of cases tested (8/38).
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
AbstractKey contentThe World Health Organization (WHO) type 1 anovulatory disorders include hypogonadotrophic hypogonadism, hypothalamic amenorrhoea and hypopituitarism.These conditions are encountered primarily in endocrine, gynaecology and reproductive medicine clinics, and can result in amenorrhoea/oligomenorrhoea, subfertility or pregnancy loss.These conditions are associated with estrogen deficiency and therefore have implications for long ‐term bone and cardiovascular health.There is an apparent lack of clarity on diagnostic criteria (including utility of new biomarkers such as anti ‐müllerian hormone) and m...
Source: The Obstetrician and Gynaecologist - Category: OBGYN Authors: Tags: REVIEWS Source Type: research
According to this study: Testosterone therapy is associated with an increased short-term risk of venous thromboembolism in both men who have hypogonadism and men who do not.
Source: AJN - Category: Nursing Tags: Journal Watch Source Type: research
Condition:   Hypogonadism Intervention:   Drug: Androderm® Sponsor:   Allergan Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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