Place of Neuroimaging in Cerebral Small Vessel Disease

The burden of cerebrovascular disease is high: each year, approximately 795 000 people in the United States experience a new or recurrent stroke, leading to death in 128 824 individuals or being associated with death in 215 864 cases. However, the number of silent infarcts and microhemorrhages is much higher, causing cognitive and behavioral impairment in 17% of the population older than 65 years. These usually primarily asymptomatic events are often caused by cerebral small vessel disease (SVD) detected as white matter hyperintensities, lacunas, microbleeds, and cortical and subcortical atrophy in magnetic resonance imaging (MRI) of elderly people. These MRI changes have a high prevalence in this population. The long-term prognosis of SVD is highly variable, but functional decline and death may be a consequence.
Source: JAMA Neurology - Category: Neurology Source Type: research

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CONCLUSIONS: We identified no trials for preventing silent cerebral infarcts in adults, or in children who do not have HbSS SCD. Long-term red blood cell transfusions may reduce the incidence of silent cerebral infarcts in children with abnormal TCD velocities, but may have little or no effect on children with normal TCD velocities. In children who are at higher risk of stroke and have not had previous long-term transfusions, long-term red blood cell transfusions probably reduce the risk of stroke, and other SCD-related complications (acute chest syndrome and painful crises). In children and adolescents at high risk of str...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
We describe a new method to induce focal brain damage targeting the motor cortex to study damage to the descending motor tracts in the non-human primate. Stereotaxic injection of malonate into the primary motor cortex produced a focal lesion in middle-aged marmosets (Callithrix jacchus). Assessment of sensorimotor function using a neurological scale and testing of forelimb dexterity and strength lasted a minimum of 12  weeks. Lesion evolution was followed by magnetic resonance imaging (MRI) at 24 h, 1 week, 4 and 12 weeks post-injury and before sacrifice for immunohistochemistry. Our model produced consistent les...
Source: Translational Stroke Research - Category: Neurology Source Type: research
We report the case of a 20-year-old man with atopic dermatitis treated with dupilumab for half a year, who presented with sudden onset of dizziness, nausea, and slight cerebellar ataxia. Brain magnetic resonance imaging revealed acute infarction in the bicerebellar hemispheres.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
Randomised comparison of a balloon-expandable and self-expandable valve with quantitative assessment of aortic regurgitation using magnetic resonance imaging. Neth Heart J. 2020 Apr 03;: Authors: Kooistra NHM, Abawi M, Voskuil M, Urgel K, Samim M, Nijhoff F, Nathoe HM, Doevendans PAFM, Chamuleau SAJ, Leenders GEH, Leiner T, Abrahams AC, van der Worp HB, Agostoni P, Stella PR Abstract INTRODUCTION: Transcatheter aortic valve implantation (TAVI) is a safe and effective treatment for inoperable, intermediate- or high-risk patients with severe symptomatic aortic stenosis and has been associated ...
Source: Netherlands Heart Journal - Category: Cardiology Authors: Tags: Neth Heart J Source Type: research
Conditions:   Ischemic Stroke;   Hemorrhagic Shock Intervention:   Radiation: Brain magnetic resonance imaging (MRI) , computed tomography (CT) Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Atherosclerosis is a systemic inflammatory disease typified by the development of lipid-rich atheroma (plaques), the rupture of which are a major cause of myocardial infarction and stroke. Anatomical evaluation of the plaque considering only the degree of luminal stenosis overlooks features associated with vulnerable plaques, such as high-risk morphological features or pathophysiology, and hence risks missing vulnerable or ruptured non-stenotic plaques. Consequently, there has been interest in identifying these markers of vulnerability using either magnetic resonance imaging (MRI) for morphology, or posit...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
Conditions:   Cerebral Small Vessel Diseases;   Cerebral Small Vessel Ischemic Disease;   Lacunar Stroke Interventions:   Diagnostic Test: 7 Tesla Magnetic Resonance Imaging;   Other: Brief Memory and Executive Test Sponsors:   University of Cambridge;   Cambridge University Hospitals NHS Foundation Trust;   Wolfson Brain Imaging Centre Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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