Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, hybridization and PCR to detect Coxsackievirus B1 in A549 cells

Enterovirus1 (EV) infections are common in all age groups. They are usually asymptomatic or cause only mild respiratory symptoms, but can also lead to more severe illness including hand, foot and mouth disease, myocarditis, meningitis, encephalitis, pancreatitis, systemic infection in newborns and paralysis. EV infections may also play a role in the pathogenesis of chronic diseases such as dilated cardiomyopathy [1], chronic fatigue syndrome [2] and type 1 diabetes2 (T1D) [3–5].
Source: Journal of Clinical Virology - Category: Virology Authors: Source Type: research

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ConclusionsBased on the population data and our case series, COQ4-related mitochondriopathy is likely an underrecognized condition. We recommend including the COQ4 c.370G > A variant as a part of the screening process for mitochondriopathy in Chinese populations.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
CONCLUSIONS: The spectrum of neurological complications from dengue virus is broad. There are no reliable data on its real incidence because most of the studies published to date are isolated series or cases. PMID: 31310001 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
We report the case of a 51-year-old man who received a heart transplantation and presented with a reactivation of the disease. The molecular characterization of the parasite showed that the reactivation was related to specific infection by a DTU I (TcISYL) parasite.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Conclusion: Colo-epidural fistula can occur as a consequence of colorectal anastomotic leakage. Prior to frank neurology symptoms and sepsis, patients may present with only a low-grade fever. Without prompt and aggressive management of colo-epidural infection, this severe complication can lead to paraplegia and death. PMID: 31311450 [PubMed - as supplied by publisher]
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
AbstractBiomarkers classically studied in Alzheimer ’s disease have been analyzed in numerous central nervous system infections in adults, but there are scarce data on these biomarkers in children. Enteroviruses appear to be the most common cause of aseptic meningitis throughout the world. The aim of the study was to investigate neuroinflammatory p roperties of non-polio enteroviruses by measuring CSF concentrations of biomarkers that are involved in neuropathological pathways of neurodegenerative disorders. We measured Aβ42, t-tau, and S100B concentrations in 42 children with enteroviral meningitis (EM) compare...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Conclusion: Preserved LV EF and LVEDD remain stable over a long lasting period in the majority of patients. However, these data suggest that some patients develop reduced LV EF, even without progression of AR to severe, especially if renal insufficiency or atrial fibrillation are present. PMID: 31311434 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Authors: Av R, Sadanandan S, Thulaseedharan NK, Kg SK, Pallivalappil B, As AK Abstract Nipah Virus Infection is an emerging zoonotic infection which presents with acute encephalitis and respiratory distress syndrome. It is associated with high mortality and classified as Biosafety level 4 organisms in view of its features which make it a potential agent for Bioterrorism. Experience with broad spectrum antiviral agent Ribavirin is promising in reducing the mortality and morbidity. PMID: 31313551 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Bhagat AK, Bhardwaj H, Bhardwaj BL, Goyal S, Jaura S, Jain P Abstract Introduction: Cataract represents one of the most frequent eye complications in type 1 DM and type 2 DM patients; contrarily, acute cataract in young diabetic patients occurs very rarely. Only few cases with acute bilateral cataract - all relatively shortly after the diagnosis of type 1 DM have been reported. It can affect visual acuity from slight visual impairment to complete blindness. Although usually associated with chronic hyperglycaemia, it may also occur on rapid restoration of euglycaemia.1 Early detection of diabetes and adequa...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Publication date: Available online 17 July 2019Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): José L. Neira, Martina Palomino-Schätzlein, Caterina Ricci, Maria Grazia Ortore, Bruno Rizzuti, Juan L. IovannaAbstractIntrinsically disordered proteins (IDPs) explore diverse conformations in their free states and, a few of them, also in their molecular complexes. This functional plasticity is essential for the function of IDPs, although their dynamics in both free and bound states is poorly understood. NUPR1 is a protumoral multifunctional IDP, activated during the acute phases of pan...
Source: Biochimica et Biophysica Acta (BBA) Proteins and Proteomics - Category: Biochemistry Source Type: research
Conclusions: Daclizumab was the only recently approved monoclonal antibody associated with DRESS syndrome as such. Limitations in the diagnostic reliability of DRESS syndrome as a clinical entity and the lack of negative clinical trial reporting suggest enhanced vigilance on the part of clinicians and regulators may be warranted. PMID: 31308976 [PubMed]
Source: Autoimmune Diseases - Category: Allergy & Immunology Tags: Autoimmune Dis Source Type: research
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