Opportunities and challenges in developing relevant animal models for Alzheimer's disease.

Opportunities and challenges in developing relevant animal models for Alzheimer's disease.
Ageing Res Rev. 2016 Jan 29;
Authors: De Felice FG, Munoz DP
Abstract
A major impediment to the development of safe and effective therapeutics in Alzheimer's disease (AD) lies in difficulties in translating research findings across species: therapies that work in rodents often do not translate to humans. A route to bridge the gap between promising rodent research and the human clinical condition consists in using non-human primates (NHPs), which are phylogenetically much closer to humans. In this article, we discuss the importance of investigating disease mechanisms from cell culture, through different animal models of disease. We highlight that developing a viable, validated NHP AD model will likely be a key step toward understanding AD-relevant pathogenic mechanisms and for developing therapies that will effectively translate to the human disease condition.
PMID: 26829469 [PubMed - as supplied by publisher]

Source: Ageing Research Reviews - January 29, 2016 Category: Genetics & Stem Cells Authors: De Felice FG, Munoz DP Tags: Ageing Res Rev Source Type: research