Histamine H4 Receptor mediates interleukin-;8 and TNF-α release in human mast cells via multiple signaling pathways.

In conclusion, we found that H4R mediates the release of inflammatory cytokine TNF-α and chemokine IL-8 in human mast cells via PI3K, Ca2+-Calcineurin-NFAT and MAPKs signaling pathways. PMID: 26828993 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research