Proton beam therapy 'effective' and 'causes fewer side effects'

ConclusionThis phase II study looked at the long-term side effects of using proton radiotherapy as part of the treatment of children with medulloblastoma. The treatment was used alongside standard surgical removal and chemotherapy. The current study is reported to be the longest prospective follow-up study available on this treatment for medulloblastoma.Overall, 12% of the study's participants had severe hearing loss three years after proton radiotherapy, and 16% at five years. This was reported by the authors to be less than the equivalent 23 Gy dose of standard (photon) radiotherapy, which was said to cause hearing loss in about a quarter (25%) of those receiving it. However, as the researchers say, these comparisons are not completely reliable because of the different doses used. Cognitive impairment was also slightly less than has been observed with standard radiotherapy – 1.5 IQ points in this study, and 1.9 with photon radiotherapy in other studies. Again, the researchers caution over the differences in radiation doses used and population treated.  Progression-free and overall survival rates in this study were reported to be much the same as those using standard radiotherapy. There was also a lack of reported toxic effects to the heart, lungs or digestive system.        Overall, the results seem positive. The difficulty is that this is a non-comparative trial. All children received proton radiotherapy. There was no randomise...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Medical practice Source Type: news

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ConclusionThis endoscopy-based study revealed the most common histology of benign SB tumors were hamartoma and adenoma, and malignant ones were lymphomas, GISTs, adenocarcinomas and metastatic cancers. Most of them were male gender, except for GISTs, and with proximal location, except for lymphomas. Further large-scale investigation efforts are warranted to elucidate the epidemiology of SB tumors.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
ConclusionsThese findings linked the anti-tumor properties of PE with the immune microenvironment to present a reliable basis for the future practical application of PE in cervical cancer as a novel and pharmacologically safe immunotherapy strategy.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsThe experimental results from the pharmacological research enable the validation of their traditional uses in several of the groups of diseases in the countries of origin and reveal these plants to be a valuable source for therapeutic molecules. However, more toxicity assays and clinical trials would be necessary to establish optimal and safe doses of consumption on the application of these medicinal plants.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, this study makes clear that lncRNA THOR is up-regulated in retinoblastoma, and its over-expression significantly enhances the malignant phenotype transformation of retinoblastoma cells through up-regulating c-myc expression via enhancing its combination with TGF2BP1 protein. Overall, our study illustrates that lncRNA THOR/c-myc molecular cascade might be another potent target for retinoblastoma treatment.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Conclusions: AEE protected against 5-Fu-induced intestinal mucositis (IM) in mice through mechanisms that involved in promoting the enterocyte proliferative activity, maintaining the integrity of tight junction proteins, inhibiting oxidative stress and ameliorating the inflammatory disturbances. Accordingly, A. agallocha may be a promising therapeutic candidate used for the prevention of IM during cancer chemotherapy.Graphical abstractThe results of this study gave a scientific support for the protection of AEE on 5-Fu-induced IM in mice through mechanisms that involved in promoting the enterocyte proliferative activity, m...
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 20 July 2018Source: Cancer EpidemiologyAuthor(s): E.E. Jedy-Agba, E.O. Dareng, S.N. Adebamowo, M. Odutola, E.A. Oga, F. Igbinoba, T. Otu, E. Ezeome, F. Bray, R. Hassan, C.A. Adebamowo
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 20 July 2018Source: Cancer GeneticsAuthor(s): Daja Šekoranja, Emanuela Bostjančič, Vladka Salapura, Blaž Mavčič, Jože PižemAbstractAneurysmal bone cyst (ABC) is a benign but locally aggressive, mostly pediatric neoplasm, with characteristic USP6 gene rearrangement that distinguishes it from a secondary ABC and other primary bone tumors. With the advent of next-generation sequencing (NGS) technology, several hitherto unknown USP6 fusion partners have been identified in ABC. Accordingly, we present a case of an 18-year-old male with a solid sub-periosteal primary ABC in the di...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
How well do you understand skin cancer risks? Test yourself with our latest quiz, and learn about USPSF recommendations for skin cancer prevention.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
AbstractThe purpose of the present study was to examine the educational needs of patients regarding early detection of oral cancer. A total of 790 patients without cancer were interviewed and shown a set of validated clinical images of various oral lesions including early oral cancer. Participants were asked about their perception of cancer and the action that they would take if they notice a similar lesion. Lower risk lesions (e.g., lumps) were more likely to be perceived as cancer (52.4%), while higher risk lesions (e.g., red patches) were least likely to be perceived as cancer (8.8%). The perceived appearance of the les...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
This study was conducted to determine the extent of skin cancer knowledge and protective behaviors among nursing students in the West Black Sea Region of Turkey. This cross-sectional, descriptive study was conducted between February and May 2015. The study sample consisted of 965 nursing students. Data were collected by means of a questionnaire form. Nursing students had a moderate level of knowledge, with average scores of 24.35  ± 3.66. The knowledge levels of first-year students were lowest compared with other years. It was determined that, among nursing students, the percentage of “negative behav...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
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