Proton beam therapy 'effective' and 'causes fewer side effects'

ConclusionThis phase II study looked at the long-term side effects of using proton radiotherapy as part of the treatment of children with medulloblastoma. The treatment was used alongside standard surgical removal and chemotherapy. The current study is reported to be the longest prospective follow-up study available on this treatment for medulloblastoma.Overall, 12% of the study's participants had severe hearing loss three years after proton radiotherapy, and 16% at five years. This was reported by the authors to be less than the equivalent 23 Gy dose of standard (photon) radiotherapy, which was said to cause hearing loss in about a quarter (25%) of those receiving it. However, as the researchers say, these comparisons are not completely reliable because of the different doses used. Cognitive impairment was also slightly less than has been observed with standard radiotherapy – 1.5 IQ points in this study, and 1.9 with photon radiotherapy in other studies. Again, the researchers caution over the differences in radiation doses used and population treated.  Progression-free and overall survival rates in this study were reported to be much the same as those using standard radiotherapy. There was also a lack of reported toxic effects to the heart, lungs or digestive system.        Overall, the results seem positive. The difficulty is that this is a non-comparative trial. All children received proton radiotherapy. There was no randomise...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Medical practice Source Type: news

Related Links:

CONCLUSIONS Matricine induced antiproliferative effects in capan-2 human pancreatic cancer cells through inducing apoptosis, caspase activation, inhibition of cell migration and invasion, and blocking the mTOR/PI3K/AKT signalling pathway. PMID: 31005960 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS In conclusion, in view of the results of this study, it might be suggested that ferruginol might serve as an essential lead molecule for the treatment of thyroid cancer provided further in-depth studies especially studying ferruginol toxicological as well as in vivo studies are needed. PMID: 31005958 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 21 April 2019Source: Advances in Biological RegulationAuthor(s): Shaw M. Akula, Saverio Candido, Massimo Libra, Stephen L. Abrams, Linda S. Steelman, Kvin Lertpiriyapong, Giulia Ramazzotti, Stefano Ratti, Matilde Y. Follo, Alberto M. Martelli, Ramiro M. Murata, Pedro L. Rosalen, Bruno Bueno-Silva, Severino Matias de Alencar, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Weifeng Mao, Heng-Liang LinAbstractPancreatic cancer is devastating cancer worldwide with few if any truly effective therapies. Pancreatic cancer has an increasing incidence and may become the sec...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
In this study, we designed pH and redox dual-stage responsive nanocarriers in the different delivery stages for co-delivery phosphorylated curcumin (p-Cur) with doxorubicin (Dox). The MSNs nanocarriers were functionalized via specific cleavable PEGylation and hydrogel coating crosslinked by disulfide bonds: MSNs as core load Dox; p-Cur encapsulated in hydrogel coating. In blood circulation, PEGylation endow the nanocarriers with long time during blood circulation; while in tumor tissue, PEG shells could be cleaved due to the pH-sensitive bond and expose the cationic hydrogel coating to improve cell uptake; while inside tum...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 21 April 2019Source: Journal of Organometallic ChemistryAuthor(s): Margaux Elie, Gilbert Umuhire Mahoro, Eric Duverger, Jean-Luc Renaud, Richard Daniellou, Sylvain GaillardAbstractCytotoxicity of cationic (NHC)Cu(I) complexes bearing 2,2′-dipyridylamine (dpa) type ligands has been evaluated toward 4 cancer cell lines, and compared to the one of neutral (NHC)Cu(I) complexes. The high cytotoxicity of these novel cationic (NHC)Cu(I) complexes, combined with the straightforward synthesis, and versatility of dpa type ligands may offer new prospects in cancer research, toward the developm...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research
ConclusionsWe provided further evidences for implication of miR-100 and mTOR pathway in breast cancer pathogenesis.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
This study aimed to investigate the prognostic value of systemic inflammatory marker (SIM) in such patients.MethodsSeventy-seven patients who underwent curative surgery for PC with negative TMs were included in this study. Various SIMs for each patient were examined to determine the most reliable one. Using the most superior SIM, the patients were divided into two groups and their characteristics and postoperative results were compared.ResultsThe NLR was superior to other SIMs. Despite no significant intergroup differences were observed between the groups, the overall survival (OS) rate was significantly higher in the low ...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
In this study, we aimed to assess the effects of topical sesame oil in reducing the pain severity of CIP. MATERIALS AND METHODS: This randomized clinical trial was conducted on 60 patients with colorectal cancer afflicted with CIP. Patients received, twice a day for seven consecutive days, a 5-min massage solely (as the control group) or with 10 drops of sesame oil (as the experimental group) within the 10 cm radius of the affected site. The pain severity was evaluated by the visual analog scale on the first, third, fifth, and seventh days of the intervention. RESULTS: Mean changes of the pain severity compared...
Source: Complementary Therapies in Clinical Practice - Category: Complementary Medicine Authors: Tags: Complement Ther Clin Pract Source Type: research
PMID: 31003687 [PubMed - in process]
Source: Complementary Therapies in Clinical Practice - Category: Complementary Medicine Authors: Tags: Complement Ther Clin Pract Source Type: research
Abstract BACKGROUND: and Purpose: Using of herbal medicines is common for cancer treatment. The aim of this study was to determine the prevalence, reasons, and predicting factors for the use of herbal medicines by Iranian cancer patients. MATERIALS AND METHODS: We conducted this cross-sectional study on 315 cancer patients through face-to-face interview in Kerman, Southeast of Iran, 2017. RESULTS: In total, 267 (84.1%) patients used at least one herbal medicine during chemotherapy courses, while only 42 (16.1%) patients discussed the use of herbal medicines with physicians. Living in urban regions (OR, 2...
Source: Complementary Therapies in Clinical Practice - Category: Complementary Medicine Authors: Tags: Complement Ther Clin Pract Source Type: research
More News: Audiology | Brain | Brain Cancers | Brain Tumor | Cancer | Cancer & Oncology | Cancer Therapy | Cardiology | Cerebellum | Chemotherapy | Children | Gastroenterology | Health | Heart | HIV AIDS | Hormones | Laboratory Medicine | Medulloblastoma | Neurology | Pediatrics | Profits and Losses | Science | Speech-Language Pathology | Study | Toxicology | Women