A 50-year-old man with a past medical history of alcoholism presented to the ED with altered mental status, nausea, and vomiting. He is arousable but a poor historian. His girlfriend said he drinks a half-gallon of rum daily, and had his last drink two days earlier. She reported that he started to feel nauseous, vomit, and go through alcohol withdrawal. She said he also has been taking a lot of calcium carbonate for an upset stomach, but she was unable to say exactly how much. His blood pressure was 146/70 mm Hg, heart rate was 110 bpm, respiratory rate was 14 bpm, PO2 was 96% on room air, and blood glucose was 167 mg/dL. Labs are remarkable for a significant metabolic alkalosis: ABG 7.65, pCO2 69, pO2 108, and HCO3 58. The chemistry is included below. The documented lactate was 9 mmol/L, and the ethanol level was negative. The patient's ECG demonstrated a prolonged QTc of 540. The Five Toxicological Causes of Metabolic AlkalosisLoop or thiazide diuretics are a common cause of metabolic alkalosis even in therapeutic doses: Metabolic alkalosis is caused by the depletion of chloride ions and the increased delivery of sodium ions to the collecting duct. This enhances potassium ion and hydrogen ion secretion, resulting in metabolic alkalosis.Ingesting sodium bicarbonate (baking soda) for self-treatment as a home remedy: Ingesting a moderate amount of bicarbonate leads directly to an increase in serum bicarbonate and thus an alkalosis.Exces...
Publication date: Available online 26 May 2020Source: Carbohydrate PolymersAuthor(s): Bai Huang, Hui He, Hao Liu, Yue Zhang, Handong Chen, Yuanbin Ma
In conclusion, propranolol is associated with decreased risk of HCC incidence in patients with AC. PMID: 32454812 [PubMed - as supplied by publisher]
Publication date: Available online 26 May 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Yan Zhou, Yupu Liang, Mary Jeanne Kreek
Publication date: Available online 26 May 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Monica Echeverry-Rendon, Felix Echeverria, Martin C. Harmsen
Publication date: Available online 27 May 2020Source: Reactive and Functional PolymersAuthor(s): Xu Yang, Di Sha, Lei Sun, Lei Chen, Jiuduo Xu, Kai Shi, Cong Yu, Baolong Wang, Xiangling Ji
New J. Chem., 2020, Advance Article DOI: 10.1039/D0NJ01509A, PaperKulsum Bano, Srinivas Anga, Archana Jain, Hari Pada Nayek, Tarun K. Panda Synthesis of heteroleptic and homoleptic alkaline earth metal complexes supported by bulky bis-iminopyrrolyl ligands are reported. The catalytic hydroamination of isocyanates and isothiocyanates with aryl amines using calcium complex is presented. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
We report the fabrication of permeable membranes for microfluidic dialysis applications in poly(dimethylsiloxane) (PDMS) channels. A maskless UV projection device was used to photo-pattern long hydrogel membranes (mm-cm) with a... The content of this RSS Feed (c) The Royal Society of Chemistry
Publication date: Available online 26 May 2020Source: American Journal of Kidney DiseasesAuthor(s): Sai Sudha Mannemuddhu, Heather A. Morgans, Naile Tufan Pekkucuksen, Bradley A. Warady, Lawrence R. Shoemaker
This article explores the question of what we can consider to be real in drug policy. It examines two increasingly common aspects of drug policy analysis; radical constructionist critique and successionist data science. It shows how researchers using these...
INTRODUCTION: Alcohol use and suicidality remain serious risks for U.S. youth. Research has established that disparities exist in these outcomes between heterosexual and sexual minority youth. However, research into the associations between alcohol use and...
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