Identification of upstream regulators for synovial expression signature genes in osteoarthritis

Conclusion This integrated analysis has identified the OA signature, providing clues to pathogenesis of OA at the molecular level, which may be also used as diagnostic markers for OA. Some crucial upstream regulators, such as NR4A2, EHF, and EGR1 may be considered as potential new therapeutic targets for OA.

Source: Joint Bone Spine - January 30, 2016 Category: Orthopaedics Source Type: research