Next Generation Sequencing Reveals Restriction and Clonotypic Expansion of Regulatory T Cells in Juvenile Idiopathic Arthritis

Conclusions: Our data identified restriction and clonotypic expansions in the JIA Treg repertoire with sharing of Treg clonotypes across arthritis patients. These findings suggest that abnormalities in the Treg repertoire, possibly engendered by shared antigenic triggers, may contribute to disease pathogenesis in JIA. This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fart.39606

Source: Arthritis and Rheumatism - January 27, 2016 Category: Rheumatology Authors: Lauren A. Henderson, Stefano Volpi, Francesco Frugoni, Erin Janssen, Susan Kim, Robert P. Sundel, Fatma Dedeoglu, Mindy S. Lo, Melissa M. Hazen, Mary Beth Son, Ronald Mathieu, David Zurakowski, Neng Yu, Tatiana Lebedeva, Robert C. Fuhlbrigge, Jolan E. Wal Tags: Full Length Source Type: research