Paraneoplastic limbic and extra-limbic encephalitis secondary to a thymoma mimicking an acute stroke.
Paraneoplastic limbic and extra-limbic encephalitis secondary to a thymoma mimicking an acute stroke. Can J Neurol Sci. 2016 Jan 22;:1-4 Authors: Reginold W, Ninan K, Coret-Simon J, Haider E PMID: 26795210 [PubMed - as supplied by publisher]
Contributors : Ashley McDonough ; Richard V Lee ; Shahani Noor ; Chungeun Lee ; Thu Le ; Michael Iorga ; Jessica L Phillips ; Sean Murphy ; Thomas M öller ; Jonathan R WeinsteinSeries Type : Expression profiling by arrayOrganism : Mus musculusStroke is the fifth leading cause of death in the United States and is a leading cause of serious long-term disability worldwide. Innate immune responses are critical in stroke pathophysiology, and microglia are key cellular effectors in the CNS response to ischemia/reperfusion. Using a transcriptional analysis approach, we identified a robust interferon (IFN)-stimulated gene res...
Contributors : Bing Han ; Honghong YaoSeries Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Mus musculusAstrocyte activation is involved in the context of stroke. Our study provides a potential new therapeutic strategy to astrocyte activation in the context of stroke.
Hypertension (HTN) has been implicated as a risk factor for stroke in continuous-flow Left Ventricular Assist Device (LVAD) populations. Active treatment of HTN has been shown to decrease cerebrovascular accident rates in the recent trial. Current guidelines recommend a mean arterial pressure (MAP) of 80mmHg in LVAD patients; however, it is difficult to reliably measure Blood Pressure (BP) in this cohort. Increased BP will further affect pump output since LVAD flows are altered by both preload and afterload.
Bleeding is the most common complication of left ventricular assist device (LVAD) placement. However, excessive transfusion has been linked to heart failure, stroke, and alloimmunization. We compared 90-day outcomes in patients receiving a blood conservation (BCS) versus liberal transfusion strategy during surgery and the subsequent 24 hours.
Advanced heart failure predisposes patients to intracardiac thrombus (ICT) formation. There is a paucity of evidence examining the impact of pre-existing left atrial (LA) or left ventricular (LV) thrombi on post-operative outcomes in patients undergoing durable LVAD implantation.
The initial project of ACTION (Advanced Cardiac Therapies Improving Outcomes Network) is focused on improving stroke rates in patients implanted with a ventricular assist devices (VAD) in participating centers. The initial interventions targeted improving communication, anticoagulation, and blood pressure management. We sought to describe the characteristics and outcomes of patients implanted with intracorporeal, continuous flow VADs (cfVAD).
Pulmonary vascular resistances (PVR) are among the key measurements derived from right heart catheterization (RHC) in the prognostic assessment of patients (pts) candidate to Heart Transplantation (HT). PVR however don't account for compliance and pulsatility of pulmonary circulation. Pulmonary arterial compliance (PAC) [stroke volume/pulmonary artery pulse pressure (SV/PAPP)], that is inversely related to PVR, and pulmonary effective arterial elastance (Ea) (sPAP/SV) incorporate compliance and pulsatility of right ventricular afterload.
by Malathi Latha Perugula, MD, and Steven Lippmann, MD The authors are from the Department of Psychiatry and Behavioral Science, University of Louisville School of Medicine, Louisville, Kentucky. Innov Clin Neurosci. 2016;13(11–12):41–42 This column series compares neurological conditions that pose differential challenges in diagnoses. Funding: No funding was provided for the preparation of this article. Financial disclosures: The authors have no conflicts of interest relevant to the content of this article. Introduction Encephalopathy and psychosis are two separate mental states that are both characterized by ...
CONCLUSIONS: C-11-PK11195 PET imaging can be useful in the diagnosis of limbic encephalitis and for monitoring response to treatment. MALT lymphoma may also be associated with autoimmune or paraneoplastic encephalitis, especially in individuals with other predisposing factors to autoimmune disorders, such as Tourette’s and autoimmune thyroid disease. The reduction in microglial activity with both IVIG and anti-psychotics supports previous findings that anti-psychotics may act through anti-inflammatory pathways.Disclosure: Dr. Shatz has received research support from Janssen Pharmaceutica. Dr. Chugani has nothing to disclose.
Objective: To report an unusual case of Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) with stroke like symptoms. Background: SREAT is a rare disorder commonly seen in females. Two clinic subtypes have been described, encephalopathic and vasculitic types. The hallmark-presenting feature is a nonspecific encephalopathy. Additional manifestations include, seizures, aphasia, extrapyramidal signs, myoclonus, gait disorder, neuropsychiatric symptoms and stroke-like episodes. Corticosteroids are the main stay of therapy. Design and methods: Case report and pertinent literature review. Results: 3...