Smokers' Lungs Pass Muster in Transplants (CME/CE)
(MedPage Today) -- Donor lungs from smokers led to transplant outcomes similar to those involving lungs of nonsmokers, British transplant specialists reported.
Discussion Severe-combined immunodefiency (SCID) is actually a group of inherited disorders with an absence or dysfunction of T, B and NK cells that results in severe dysfunction of the immune system. SCID is a primary immunodeficiency. SCID was thought to be a rare disorder but with the advent of neonatal screening the incidence in the US general population is estimated at ~1 in 58,000 live births, but with numbers higher or lower depending on the specific population. Patients often have failure to thrive, oral candidiasis, and diarrhea as infants as well as a variety of infectious diseases. They can also have interstit...
Conclusions. The xenograft murine model using adult human PBMC and cord blood derived CD34+ HSCs could be alternative experimental systems to model human aGvHD and cGvHD for investigating disease mechanisms and evaluating treatment strategy.DisclosuresNo relevant conflicts of interest to declare.
Conclusion:Sir/Tac has a more profound T-cell suppressive effect than the standard of care combination of Tac/MTX in the early post-transplant period, and particularly compromises recovery of CD8+ T-cells with potential implications in the prevention of aGVHD. Sirolimus when used in-vivo with tacrolimus does not result in increased absolute numbers of Tregs, however it does have a beneficial effect on the Treg:Tcon balance in the first 3 months after transplantation, which may be important in the context of cGVHD prevention. Calcineurin-inhibitor free, sirolimus containing GVHD prophylaxis strategies, incorporating other n...
The classical Th2 cytokines interleukin 13 (IL13) and 5 (IL5) play an important role in the development of allergies and asthma due to their role in leukocyte recruitment and tissue remodeling. However, IL13 has also been implicated as a major driver of tissue fibrosis. Up to 50% of lung transplant recipients develop fibrotic disease 5-years post-transplantation despite immunosuppressive treatment based on calcineurin inhibitors (CNIs). To investigate the correlation between CNIs and IL13, we isolated naïve and memory T cells from blood of healthy donors and activated with aCD3/aCD28 coated Dynabeads and cytokine cocktai...
Conclusion: Our results suggest that NOD1-deficient dysbiosis is not responsible for decreasing allergic inflammation parameters and suggest that the allergen may directly activate NOD1 receptor.
Conclusion: We identified production of IL-17A among populations of ILCs, gamma delta T cells and iNKT cells in different lung disease entities which suggests that these cell populations can contribute to IL-17A-dependent pathologies in end stage lung disease.
CONCLUSIONS: Interestingly, acute fulminant infection or sinusitis complications in solid organ transplant patients were much lower than expected. CRS in this patient group was less frequent than expected as well. Whether chronic immunosuppression minimizes the likelihood for CRS deserves further investigation. A more surgically oriented approach in CRS patients may be favored early in the management course of medically refractory patients in light of patients excellent outcomes. PMID: 30362361 [PubMed - as supplied by publisher]
Penicillin allergy is the most frequently reported drug hypersensitivity reaction with a prevalence rate of around 10% in the US 1,2; however, true reactions exist in only around 3% of patients reporting a penicillin allergy 2. Penicillin allergy stigma results in higher health care costs and increased prevalence of multidrug resistant (MDR) organisms. In the pre-lung transplant population there are no data on penicillin skin testing in the setting of severely compromised lung function.
PMID: 30213612 [PubMed - as supplied by publisher]
CONCLUSIONS: Preventive treatment with TolDCs protects against dust mite-induced allergy in a mouse model, reinforcing the use of tolerogenic dendritic cells for the management of allergic conditions. PMID: 29949837 [PubMed]