Smokers' Lungs Pass Muster in Transplants (CME/CE)

(MedPage Today) -- Donor lungs from smokers led to transplant outcomes similar to those involving lungs of nonsmokers, British transplant specialists reported.
Source: MedPage Today Allergy - Category: Allergy & Immunology Source Type: news

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While most people are familiar with the hallmark symptoms of COVID-19 by now—cough, fever, muscle aches, headaches and difficulty breathing—a new crop of medical conditions are emerging from the more than 4 million confirmed cases of the disease around the world. These include skin rashes, diarrhea, kidney abnormalities and potentially life-threatening blood clots. It’s not unusual for viruses to directly infect and affect different tissues and organs in the body, but it is a bit unusual for a primarily respiratory virus like SARS-CoV-2, which is responsible for COVID-19, to have such a wide-ranging reach...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
There has been greater recognition of allergy and autoimmune disease in pediatric solid organ transplantation, however, their relationship with pediatric heart transplant is unclear. The purpose of this study was to explore post heart transplant immune dysregulation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1155) Source Type: research
Health-related quality of life (HRQoL) is a patient-centered measure of outcomes based on patient-perceived physical and mental health. We hypothesized that pre-lung transplant Immunoglobulin levels would be associated with post-transplant HRQoL measures.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
We have previously reported that fewer than 30% protective pretransplant pneumococcal antibody levels were significantly related to severe hypogammaglobulinemia (HGG) after lung transplantation. Prospective studies have not been performed to evaluate associations of individual pneumococcal antibody levels with outcomes in lung transplant (LT) population.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
UCLA researchers are part of an international team that reported the use of a stem cell gene therapy to treat nine people with the rare, inherited blood disease known as X-linked chronic granulomatous disease, or X-CGD. Six of those patients are now in remission and have stopped other treatments. Before now, people with X-CGD – which causes recurrent infections, prolonged hospitalizations for treatment, and a shortened lifespan – had to rely on bone marrow donations for a chance at remission.“With this gene therapy, you can use a patient’s own stem cells instead of donor cells for a transplant,&rdqu...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
This article is protected by copyright. All rights reserved. PMID: 31991477 [PubMed - as supplied by publisher]
Source: European Journal of Immunology - Category: Allergy & Immunology Authors: Tags: Eur J Immunol Source Type: research
The effect of hypogammaglobulinemia on post-transplant outcomes and the role of intravenous immunoglobulin (IVIG) in patients who have undergone lung transplant is unknown. No guidelines have been established for the use of IVIG in patients who have undergone solid organ transplantation.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
We present a patient without known food allergy, who acquired peanut sensitization after bilateral lung transplantation from his organ donor.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
A drug developed by UCLA physician-scientists and chemists speeds up the regeneration of mouse and human blood stem cells after exposure to radiation. If the results can be replicated in humans, the compound could help people recover quicker from chemotherapy, radiation and bone marrow transplants.The study, published in Nature Communications,also sheds light on the basic biology behind blood stem cell regeneration and the role of a specific molecular process that is blocked by the new drug. Blood stem cells reside in the bone marrow and produce all of the body ’s blood and immune cells.“We’re very excite...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Discussion MDSCs violently emerge in pathological conditions in an attempt to limit potentially harmful immune and inflammatory responses. Mechanisms supporting their expansion and survival are deeply investigated in cancer, in the perspective to reactivate specific antitumor responses and prevent their contribution to disease evolution. These findings will likely contribute to improve the targeting of MDSCs in anticancer immunotherapies, either alone or in combination with immune checkpoint inhibitors. New evidence indicates that the expansion of myeloid cell differentiation in pathology is subject to fine-tuning, as its...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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