This month’s most missed USMLE question--and the right answer

As you prepare for the United States Medical Licensing Exam® (USMLE®), do you know which questions to look out for? We’re giving you an exclusive scoop on the most challenging USMLE test prep questions and expert strategies to help you beat them. Find out what this month’s toughest question is and receive an expert video explanation of the answer from Kaplan Medical. Welcome to the third post in AMA Wire’s® series, “Tutor talk: Tips from Kaplan Medical on the most missed USMLE test prep questions.” Each month, we’re revealing one of the top questions students miss, a helpful analysis of answers and a video featuring tips on how to advance your test-taking strategies. This month’s question explores pathology and cardiovascular topics. Ready. Set. Go. This month’s question that stumped most students: A 72-year-old obese woman collapses and is brought to the emergency department. She flew from California to New York three days earlier. She has smoked a pack of cigarettes daily for 50 years. During physical examination, she is unable to respond to questions or follow instructions. Three days later, she becomes hypotensive and dies. Autopsy shows multiple loosely adherent clots within the distal branching arteries of the left middle cerebral artery and in the vertebrobasilar system. Which of the following pathologic conditions would most likely account for the neurologic findings in this pati...
Source: AMA Wire - Category: Journals (General) Authors: Source Type: news

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Publication date: 17 July 2018Source: Cell Reports, Volume 24, Issue 3Author(s): Alice H. Hsu, Michelle A. Lum, Kang-Sup Shim, Peter J. Frederick, Carl D. Morrison, Baojiang Chen, Subodh M. Lele, Yuri M. Sheinin, Takiko Daikoku, Sudhansu K. Dey, Gustavo Leone, Adrian R. Black, Jennifer D. BlackSummaryProtein kinase C (PKC) isozymes are commonly recognized as oncoproteins based on their activation by tumor-promoting phorbol esters. However, accumulating evidence indicates that PKCs can be inhibitory in some cancers, with recent findings propelling a shift in focus to understanding tumor suppressive functions of these enzyme...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 17 July 2018Source: Cell Reports, Volume 24, Issue 3Author(s): James Monypenny, Hanna Milewicz, Fabian Flores-Borja, Gregory Weitsman, Anthony Cheung, Ruhe Chowdhury, Thomas Burgoyne, Appitha Arulappu, Katherine Lawler, Paul R. Barber, Jose M. Vicencio, Melanie Keppler, Wahyu Wulaningsih, Sean M. Davidson, Franca Fraternali, Natalie Woodman, Mark Turmaine, Cheryl Gillett, Dafne Franz, Sergio A. QuezadaSummaryThe immunosuppressive transmembrane protein PD-L1 was shown to traffic via the multivesicular body (MVB) and to be released on exosomes. A high-content siRNA screen identified the endosomal sorting co...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 17 July 2018Source: Cell Reports, Volume 24, Issue 3Author(s): Mayura V. Wagle, Julia M. Marchingo, Jason Howitt, Seong-Seng Tan, Christopher C. Goodnow, Ian A. ParishSummaryEscape from peripheral tolerance checkpoints that control cytotoxic CD8+ T cells is important for cancer immunotherapy and autoimmunity, but pathways enforcing these checkpoints are mostly uncharted. We reveal that the HECT-type ubiquitin ligase activator, NDFIP1, enforces a cell-intrinsic CD8+ T cell checkpoint that desensitizes TCR signaling during in vivo exposure to high antigen levels. Ndfip1-deficient OT-I CD8+ T&...
Source: Cell Reports - Category: Cytology Source Type: research
Authors: Choung S, Joung KH, You BR, Park SK, Kim HJ, Ku BJ Abstract Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance. The peroxisome proliferator-activated receptor (PPAR) activators, thiazolidinediones, (TZDs), are insulin sensitizers used as a treatment for NAFLD. However, TZDs are a controversial treatment for NAFLD because of conflicting results regarding hepatic steatosis and fibrosis. To evaluate a possible effective drug for treatment of NAFLD, we investigated the effects of a newly developed TZD, lobeglitazone, with an emphasis on hepatic lipid metabolism. Lobeglitazo...
Source: PPAR Research - Category: Genetics & Stem Cells Tags: PPAR Res Source Type: research
MIDNIGHT fridge raiders are more at risk of developing breast or prostate cancer, research revealed last night.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: Comorbidities have a negative prognostic impact on overall survival in cancer patients, and should be assessed as risk factors for mortality when reporting outcomes. PMID: 30012908 [PubMed - as supplied by publisher]
Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
CONCLUSION: We found a high mean BMI and high prevalence of overweight/obesity and hypertriglyceridemia, but low mean total cholesterol and a low prevalence of hypercholesterolemia in Palau. Lipid profiles varied by age, ethnicity, and living area. PMID: 30012907 [PubMed - as supplied by publisher]
Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
Publication date: Available online 17 July 2018Source: The Annals of Thoracic SurgeryAuthor(s): Samuel Jacob, Erol V. BelliAbstractElectric shock–induced myocardial infarction is rare. Shock-induced coronary artery thrombosis and dissection in multiple distributions have not been reported. After shock, coronary thrombosis may cause anginal symptoms, and any coronary artery may be damaged. A 32-year-old man presented with angina and ischemia-related symptoms post 6,000-V electric shock. He reported occasional exertional angina; stress echocardiography was positive for ischemia. Catheterization showed severe multivesse...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 17 July 2018Source: The Annals of Thoracic SurgeryAuthor(s): Ju-Dong Li, Zi-Long Xiao, Xiao-Xiang Hou
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusions: Given the performance of the PBIC, it would be highly appropriate to use the device for therapeutic infusions in human clinical trials to assess its capability for large-volume infusions.Stereotact Funct Neurosurg
Source: Stereotactic and Functional Neurosurgery - Category: Neurosurgery Source Type: research
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