Luts in pelvic ischemia: a new concept in voiding dysfunction.

LUTS IN PELVIC ISCHEMIA: A NEW CONCEPT IN VOIDING DYSFUNCTION. Am J Physiol Renal Physiol. 2016 Jan 20;:ajprenal.00333.2015 Authors: Thurmond P, Yang JH, Azadzoi KM Abstract Lower urinary tract symptoms (LUTS) are a group of voiding symptoms affecting both genders as they age. Traditionally, LUTS in men were commonly attributed to bladder outlet obstruction (BOO) due to benign prostatic enlargement. It was later shown that, in approximately one third to more than one half cases, LUTS in men are not associated with BOO. Urodynamic changes in the male bladder and symptom scores in the aging men were found to be identical to their age-matched female counterparts. These observations suggested that LUTS in the elderly do not necessarily relate to BOO and may result from local changes in bladder wall. However, aging factors predisposing to bladder dysfunction and LUTS remain unknown. Growing evidence suggests that pelvic ischemia may be a primary factor in the development of non-obstructed non-neurogenic overactive bladder and LUTS. First identified in experimental models and later in clinical studies, pelvic ischemia has been shown to compromise lower urinary tract structure and lead to dysfunction. Structural and functional consequences of bladder and prostate ischemia have been documented in animal models. Clinical studies have shown that bladder and prostate blood flow decreases with aging. The severity of LUTS in the elderly patients ...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research