A Role for 3D Printing in Kidney-on-a-Chip Platforms

Abstract The advancement of “kidney-on-a-chip” platforms—submillimeter-scale fluidic systems designed to recapitulate renal functions in vitro—directly impacts a wide range of biomedical fields, including drug screening, cell and tissue engineering, toxicity testing, and disease modeling. To fabricate kidney-on-a-chip technologies, researchers have primarily adapted traditional micromachining techniques that are rooted in the integrated circuit industry; hence the term “chip.” A significant challenge, however, is that such methods are inherently monolithic, which limits one’s ability to accurately recreate the geometric and architectural complexity of the kidney in vivo. Better reproduction of the anatomical complexity of the kidney will allow for more instructive modeling of physiological and pathophysiological events. Emerging additive manufacturing or “three-dimensional (3D) printing” techniques could provide a promising alternative to conventional methodologies. In this article, we discuss recent progress in the development of both kidney-on-a-chip platforms and state-of-the-art submillimeter-scale 3D printing methods, with a focus on biophysical and architectural capabilities. Lastly, we examine the potential for 3D printing-based approaches to extend the efficacy of kidney-on-a-chip systems.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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AbstractIschemia-reperfusion injury (IRI) is an inevitable consequence of kidney transplantation (KT). The aim of our study was to investigate the protective effect of a glycogen synthase kinase 3 β (GSK-3β) inhibitor against cold IRI in a rat renal transplantation (RT) model and a rat cold-IRI model through the toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor κ-light-chain-enhancer of the activated B cell (NF-κB) signaling pathway. We treated Sprague D awley (SD) rats in the RT and cold-IRI models with 5 mg/kg and 1 mg/kg, respectively, of the GSK-3β...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
In the above-stated article, the bold data in Table  1 have been revised.
Source: Kidney International - Category: Urology & Nephrology Tags: Corrigendum Source Type: research
A 39-year-old male, live-related renal transplant recipient with stable graft function presented with multiple painless, non-itchy, papular lesions over the midback region. Three months later, these lesions became multiple abscesses with pus exudation (Figure  1). The patient had a history of injury to his midback from the sharp edge of cement stairs, which caused an abrasion. He had received a thymoglobulin induction and was on prednisolone, tacrolimus, and azathioprine. The microscopic examination of KOH mount of pus revealed multiple, septate, branch ing, brown-pigmented hyphae with thick-walled vesicular swellings...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
Contrast-induced nephropathy (CIN) is a dreaded complication of peripheral vascular interventions (PVIs), especially for kidney transplant recipients (KTRs). However, the incidence of and factors associated with CIN in that population of patients have not been studied.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Abstract from the 2019 New England Society for Vascular Surgery Annual Meeting Source Type: research
A 60-year-old African American male on immunosuppression for recent kidney transplant, who initially complained of multiple symptoms, including laryngitis, productive cough, nausea, vomiting, diarrhea, fatigue, and rib pain, was admitted and intubated secondary to critical hemorrhagic shock from frank alveolar hemorrhage on bronchoalveolar lavage. This was initially thought to be vasculitic in nature by primary team and consultants following a broad and unremarkable workup, including BAL cultures, stains, and cytology.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Authors: Heidary Rouchi A PMID: 31422396 [PubMed - in process]
Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
CONCLUSION: Glucocorticoids is the the mainstay of treatment. Therenal function tests, of the vast majority of patients, normalizedwith treatment. Relapse may occur, so a follow-up over a longperiod of time is required. A high index of suspicion is neededfor diagnosis in asymptomatic patients. PMID: 31422391 [PubMed - in process]
Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
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Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
Authors: Saidi RF, Moghadasali R, Shekarchian S Abstract There has been ample of preclinical and animal studies whichshowed efficacy and safety of using mesenchymal stem cells (MSCs)after transplantation for tissue repair, immunosuppression ortolerance induction. However, there has been a significant progressrecently using MSCs in small clinical trials after transplantation. Recent results using MSCs after transplantation seem to befeasible and safe. However, there are some limitations to show theeffectiveness of these cells including source, dose, timing and routeof infusions. Currently, live donor kidney transpla...
Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
Insights from the survival analyses recommend possible inclusion of functional status into Scientific Registry of Transplant Recipients'risk-adjusted models.
Source: RAND Research Health and Health Care - Category: Health Management Authors: Source Type: research
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