Mitochondrial troublemakers unmasked in lupus

Mitochondria could provoke the inflammation characteristic of lupus, an autoimmune disorder affecting the joints, skin, heart and brain. Byproducts of cells' power stations goad certain white blood cells into making mesh traps as a precursor to cell death. Mitochondrial DNA is spewed out, triggering a warning and a response that can damage various organ tissues. Mouse studies suggest this disease mechanism might respond to potential drug therapies.
Source: ScienceDaily Headlines - Category: Science Source Type: news