Oral Squamomelanocytic Tumour in a Dog: a Unique Biphasic Cancer

Publication date: Available online 21 January 2016 Source:Journal of Comparative Pathology Author(s): L.V. Muscatello, G. Avallone, C. Benazzi, G. Sarli, I. Porcellato, C. Brachelente, B. Brunetti In human medicine, squamomelanocytic tumour is a malignant cutaneous neoplasm composed of closely intermingled neoplastic squamous cells and melanocytes. A multinodular gingival tumour in a 16-year-old, mixed breed neutered female dog was examined microscopically. Two populations of neoplastic cells, melanocytic and squamous epithelial cells were intermingled. The melanocytic cells were melan-A positive and cytokeratin AE1–AE3 negative and the squamous component was cytokeratin AE1–AE3 positive and melan-A negative. Bovine papillomavirus was not identified by immunohistochemistry or polymerase chain reaction. A diagnosis of squamomelanocytic tumour was made.
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research