Mismatch repair deficiency may affect clinical outcome through immune response activation in metastatic gastric cancer patients receiving first-line chemotherapy

Conclusions Our analysis confirms the favorable prognosis of metastatic gastric cancer patients with a defective MMR system and suggests that expression of TILs might also be linked to better outcome. Because of the correlation between defective MMR status and measures of immune system activity, this group of patients would be the best candidates for novel immunotherapy-based therapies.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research

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Cancer Gene Therapy, Published online: 16 July 2019; doi:10.1038/s41417-019-0125-7Discovery and validation of methylated-differentially expressed genes in Helicobacter pylori-induced gastric cancer
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
ConclusionsThis case highlights the importance of genetic testing with rare malignancies because the full scope of phenotypic sequelae for known hereditary syndromes has not been mapped.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Condition:   Gastric Cancer Intervention:   Sponsors:   Fundación para la Investigación del Hospital Clínico de Valencia;   Instituto Nacional de Cancerologia de Mexico;   VU University Medical Center;   Pontificia Universidad Catolica de Chile;   Vall d'Hebron Institute of Oncology;   INSTITUTO ALEXANDER FLEMING;   Hospita l Central del IPS;   INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
A tissue ‐adhesive microparticle‐based wound dressing for promoting wound healing after endoscopic surgery is demonstrated. Sprayable dressing of hydrophobized microparticles exhibits the multifunctionality necessary for wound healing including tissue adhesiveness, blood coagulation, re ‐epithelialization, and angiogenesis based on hydrophobic interaction with biological systems. An in vivo feasibility study using swine gastric endoscopic submucosal dissection models reveals suppression of fibrosis and promotion of wound healing. AbstractEndoscopic submucosal dissection (ESD) provides strong therapeutic benefits for ...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
Lynch syndrome is the most common inherited cause of gastrointestinal cancer and increases risk for a variety of malignancies, including gastric cancer. We aimed to identify clinical factors associated with gastric cancer in carriers of germline variants causing Lynch syndrome.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
ConclusionsBoth BIRIP and CPT-11 may be good therapeutic options for patients with AGC as second-line treatment.Clinical trial registrationUMIN 000025367.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
Cancer Gene Therapy, Published online: 15 July 2019; doi:10.1038/s41417-019-0118-6MicroRNA-4268 inhibits cell proliferation via AKT/JNK signalling pathways by targeting Rab6B in human gastric cancer
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
Source: Nutrition and Cancer - Category: Cancer & Oncology Authors: Source Type: research
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