Progenitor cells: Promotion of nephron progenitor cell self-renewal

Nature Reviews Nephrology 12, 62 (2016). doi:10.1038/nrneph.2015.213 Author: Jessica K. Edwards BMP, FGF, and WNT signalling regulate self-renewal of nephron progenitor cells (NPCs). A molecular analysis by Muthukrishnan et al. to delineate these pathways found that BMP7 activates TAK1 and JNK, resulting in JUN phosphorylation, Myc and Ccnd1 transcriptional regulation, and NPC
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research